Androgen Signaling in Uterine Diseases: New Insights and New Targets
Common uterine diseases include endometriosis, uterine fibroids, endometrial polyps, endometrial hyperplasia, endometrial cancer, and endometrial dysfunction causing infertility. Patients with uterine diseases often suffer from abdominal pain, menorrhagia, infertility and other symptoms, which serio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/11/1624 |
| _version_ | 1797468995343876096 |
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| author | Mu Lv Juanjuan Yu Yan Huang Jie Ma Jun Xiang Yanqiu Wang Linxia Li Zhenbo Zhang Hong Liao |
| author_facet | Mu Lv Juanjuan Yu Yan Huang Jie Ma Jun Xiang Yanqiu Wang Linxia Li Zhenbo Zhang Hong Liao |
| author_sort | Mu Lv |
| collection | DOAJ |
| description | Common uterine diseases include endometriosis, uterine fibroids, endometrial polyps, endometrial hyperplasia, endometrial cancer, and endometrial dysfunction causing infertility. Patients with uterine diseases often suffer from abdominal pain, menorrhagia, infertility and other symptoms, which seriously impair their health and disturb their lives. Androgens play important roles in the normal physiological functions of the uterus and pathological progress of uterine diseases. Androgens in women are synthesized in the ovaries and adrenal glands. The action of androgens in the uterus is mainly mediated by its ligand androgen receptor (AR) that regulates transcription of the target genes. However, much less is known about the signaling pathways through which androgen functions in uterine diseases, and contradictory findings have been reported. This review summarizes and discusses the progress of research on androgens and the involvement of AR in uterine diseases. Future studies should focus on developing new therapeutic strategies that precisely target specific AR and their related signaling pathways in uterine diseases. |
| first_indexed | 2024-03-09T19:14:11Z |
| format | Article |
| id | doaj.art-6ddf589784f94376bf4e4eba0f656788 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T19:14:11Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-6ddf589784f94376bf4e4eba0f6567882023-11-24T03:53:36ZengMDPI AGBiomolecules2218-273X2022-11-011211162410.3390/biom12111624Androgen Signaling in Uterine Diseases: New Insights and New TargetsMu Lv0Juanjuan Yu1Yan Huang2Jie Ma3Jun Xiang4Yanqiu Wang5Linxia Li6Zhenbo Zhang7Hong Liao8Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, ChinaDepartment of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, ChinaDepartment of Urology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaReproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaDepartment of Obstetrics and Gynecology, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, 358 Datong Road, Shanghai 200137, ChinaReproductive Medicine Center, Department of Obstetrics and Gynecology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, ChinaDepartment of Clinical Laboratory Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200040, ChinaCommon uterine diseases include endometriosis, uterine fibroids, endometrial polyps, endometrial hyperplasia, endometrial cancer, and endometrial dysfunction causing infertility. Patients with uterine diseases often suffer from abdominal pain, menorrhagia, infertility and other symptoms, which seriously impair their health and disturb their lives. Androgens play important roles in the normal physiological functions of the uterus and pathological progress of uterine diseases. Androgens in women are synthesized in the ovaries and adrenal glands. The action of androgens in the uterus is mainly mediated by its ligand androgen receptor (AR) that regulates transcription of the target genes. However, much less is known about the signaling pathways through which androgen functions in uterine diseases, and contradictory findings have been reported. This review summarizes and discusses the progress of research on androgens and the involvement of AR in uterine diseases. Future studies should focus on developing new therapeutic strategies that precisely target specific AR and their related signaling pathways in uterine diseases.https://www.mdpi.com/2218-273X/12/11/1624androgenandrogen receptoruterine diseasesendometrium |
| spellingShingle | Mu Lv Juanjuan Yu Yan Huang Jie Ma Jun Xiang Yanqiu Wang Linxia Li Zhenbo Zhang Hong Liao Androgen Signaling in Uterine Diseases: New Insights and New Targets Biomolecules androgen androgen receptor uterine diseases endometrium |
| title | Androgen Signaling in Uterine Diseases: New Insights and New Targets |
| title_full | Androgen Signaling in Uterine Diseases: New Insights and New Targets |
| title_fullStr | Androgen Signaling in Uterine Diseases: New Insights and New Targets |
| title_full_unstemmed | Androgen Signaling in Uterine Diseases: New Insights and New Targets |
| title_short | Androgen Signaling in Uterine Diseases: New Insights and New Targets |
| title_sort | androgen signaling in uterine diseases new insights and new targets |
| topic | androgen androgen receptor uterine diseases endometrium |
| url | https://www.mdpi.com/2218-273X/12/11/1624 |
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