Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis
Objective: To determine if there exists an upper limit for amount of blood transfused in trauma patients before it reaches a point of futility.Methods: A prospective cohort study was conducted on 131 patients who received massive blood transfusion (MBT), defined as 10 U or higher of PRBCs received i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2018-07-01
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| Series: | Bulletin of Emergency and Trauma |
| Subjects: | |
| Online Access: | http://beat.sums.ac.ir/article_44437_928bba90105fffeaaa676a9df49a1b48.pdf |
| _version_ | 1819052276333936640 |
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| author | Steven Liu Quinn Fujii Farris Serio Andrew McCague |
| author_facet | Steven Liu Quinn Fujii Farris Serio Andrew McCague |
| author_sort | Steven Liu |
| collection | DOAJ |
| description | Objective: To determine if there exists an upper limit for amount of blood transfused in trauma patients before it reaches a point of futility.Methods: A prospective cohort study was conducted on 131 patients who received massive blood transfusion (MBT), defined as 10 U or higher of PRBCs received in the initial 24 hours. Data collected from a Level II trauma center registry were used to analyze reports of adult patients from July 2014 to 2017. Cohorts were divided by amount of blood received - 0 to 9 U, 10-19 U, 20 to 29 U, 30-39 U, 40 U or higher - odds ratio for mortality and p-values for mean Injury Severity Score and overall hospital length of stay were calculated for each group.Results: Odds ratios for massive blood transfusion groups from 10 units to 39 units each contained the null value, while our 40 units and above group did not (OR 12.52, 95% CI 1.3-117.7).Conclusion: Although this study is limited by its sample size, these results suggests that 40 units of PRBCs may be a threshold at which survival rates begin to decrease significantly. |
| first_indexed | 2024-12-21T12:17:16Z |
| format | Article |
| id | doaj.art-6de1f1dc1b5c493caa70de72760ddd27 |
| institution | Directory Open Access Journal |
| issn | 2322-2522 2322-3960 |
| language | English |
| last_indexed | 2024-12-21T12:17:16Z |
| publishDate | 2018-07-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Bulletin of Emergency and Trauma |
| spelling | doaj.art-6de1f1dc1b5c493caa70de72760ddd272022-12-21T19:04:24ZengShiraz University of Medical SciencesBulletin of Emergency and Trauma2322-25222322-39602018-07-016Issue 321722044437Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat AnalysisSteven LiuQuinn FujiiFarris SerioAndrew McCagueObjective: To determine if there exists an upper limit for amount of blood transfused in trauma patients before it reaches a point of futility.Methods: A prospective cohort study was conducted on 131 patients who received massive blood transfusion (MBT), defined as 10 U or higher of PRBCs received in the initial 24 hours. Data collected from a Level II trauma center registry were used to analyze reports of adult patients from July 2014 to 2017. Cohorts were divided by amount of blood received - 0 to 9 U, 10-19 U, 20 to 29 U, 30-39 U, 40 U or higher - odds ratio for mortality and p-values for mean Injury Severity Score and overall hospital length of stay were calculated for each group.Results: Odds ratios for massive blood transfusion groups from 10 units to 39 units each contained the null value, while our 40 units and above group did not (OR 12.52, 95% CI 1.3-117.7).Conclusion: Although this study is limited by its sample size, these results suggests that 40 units of PRBCs may be a threshold at which survival rates begin to decrease significantly.http://beat.sums.ac.ir/article_44437_928bba90105fffeaaa676a9df49a1b48.pdfMassive transfusionBlood transfusionTraumaBlood loss |
| spellingShingle | Steven Liu Quinn Fujii Farris Serio Andrew McCague Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis Bulletin of Emergency and Trauma Massive transfusion Blood transfusion Trauma Blood loss |
| title | Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
| title_full | Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
| title_fullStr | Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
| title_full_unstemmed | Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
| title_short | Massive Blood Transfusions and Outcomes in Trauma Patients; An Intention to Treat Analysis |
| title_sort | massive blood transfusions and outcomes in trauma patients an intention to treat analysis |
| topic | Massive transfusion Blood transfusion Trauma Blood loss |
| url | http://beat.sums.ac.ir/article_44437_928bba90105fffeaaa676a9df49a1b48.pdf |
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