Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot study
Objective To investigate the effects of discontinuing antihypertensive drugs on the characteristics of patients with frailty syndrome. Methods This prospective pilot study was conducted between March 2016 and July 2019. Among patients who visited the frailty clinic within this period, outpatients wh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-10-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605221130716 |
| _version_ | 1797989367444144128 |
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| author | Sho Hasegawa Fumihiro Mizokami Hiroki Mase Yuji Hayakawa Atsuya Shimizu Yasumoto Matsui |
| author_facet | Sho Hasegawa Fumihiro Mizokami Hiroki Mase Yuji Hayakawa Atsuya Shimizu Yasumoto Matsui |
| author_sort | Sho Hasegawa |
| collection | DOAJ |
| description | Objective To investigate the effects of discontinuing antihypertensive drugs on the characteristics of patients with frailty syndrome. Methods This prospective pilot study was conducted between March 2016 and July 2019. Among patients who visited the frailty clinic within this period, outpatients who received antihypertensive drugs at their first visit and were followed-up for about 1 year were enrolled. Participants who discontinued or continued antihypertensive drugs during 1 year of follow-up were classified into a discontinuation group or continuation group, respectively. Each domain in the Kihon checklist (KCL), fall risk score, short physical performance battery (SPPB) score, and skeletal muscle index (SMI) were assessed at the first visit and 1-year follow-up assessment, and were compared between the two groups. Results Among 498 patients who attended the frailty clinic, 78 were enrolled (discontinuation group, n = 19; continuation group, n = 59). At the first visit, SMI scores were significantly higher in the discontinuation versus continuation group. At the 1-year assessment, physical strength in the KCL for the discontinuation group and various SPPB scores for both groups were significantly improved, and the fall risk score was improved in the continuation group. Conclusion Discontinuation of antihypertensive drugs may positively affect physical performance. |
| first_indexed | 2024-04-11T08:19:07Z |
| format | Article |
| id | doaj.art-6de51161279c4ba9a6dff9b67fe1cd77 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-04-11T08:19:07Z |
| publishDate | 2022-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-6de51161279c4ba9a6dff9b67fe1cd772022-12-22T04:35:02ZengSAGE PublishingJournal of International Medical Research1473-23002022-10-015010.1177/03000605221130716Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot studySho HasegawaFumihiro MizokamiHiroki MaseYuji HayakawaAtsuya ShimizuYasumoto MatsuiObjective To investigate the effects of discontinuing antihypertensive drugs on the characteristics of patients with frailty syndrome. Methods This prospective pilot study was conducted between March 2016 and July 2019. Among patients who visited the frailty clinic within this period, outpatients who received antihypertensive drugs at their first visit and were followed-up for about 1 year were enrolled. Participants who discontinued or continued antihypertensive drugs during 1 year of follow-up were classified into a discontinuation group or continuation group, respectively. Each domain in the Kihon checklist (KCL), fall risk score, short physical performance battery (SPPB) score, and skeletal muscle index (SMI) were assessed at the first visit and 1-year follow-up assessment, and were compared between the two groups. Results Among 498 patients who attended the frailty clinic, 78 were enrolled (discontinuation group, n = 19; continuation group, n = 59). At the first visit, SMI scores were significantly higher in the discontinuation versus continuation group. At the 1-year assessment, physical strength in the KCL for the discontinuation group and various SPPB scores for both groups were significantly improved, and the fall risk score was improved in the continuation group. Conclusion Discontinuation of antihypertensive drugs may positively affect physical performance.https://doi.org/10.1177/03000605221130716 |
| spellingShingle | Sho Hasegawa Fumihiro Mizokami Hiroki Mase Yuji Hayakawa Atsuya Shimizu Yasumoto Matsui Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot study Journal of International Medical Research |
| title | Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot study |
| title_full | Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot study |
| title_fullStr | Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot study |
| title_full_unstemmed | Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot study |
| title_short | Effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients: a 1-year prospectively designed retrospective chart-review pilot study |
| title_sort | effects of discontinuation of antihypertensive drugs on frailty syndrome in outpatients a 1 year prospectively designed retrospective chart review pilot study |
| url | https://doi.org/10.1177/03000605221130716 |
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