Effectiveness and Safety of a Domestic Porcine Small Intestinal Submucosa Acellular Matrix in Rabbit Dura Mater Repairing
ObjectiveUsing New Zealand white rabbits as an animal model, the effectiveness and safety of a domestic porcine small intestinal submucosa (SIS) acellular matrix in repairing rabbit dura mater defects were evaluated by observing the physiological state, clinical manifestations, and pathological chan...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Laboratory Animal and Comparative Medicine
2022-02-01
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| Series: | Shiyan dongwu yu bijiao yixue |
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| Online Access: | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.061 |
| _version_ | 1811322481434165248 |
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| author | SUN Lidan YANG Feixia ZHANG Di CHEN Zeliang ZHANG Zhihui LI Yingjun SHI Lijun |
| author_facet | SUN Lidan YANG Feixia ZHANG Di CHEN Zeliang ZHANG Zhihui LI Yingjun SHI Lijun |
| author_sort | SUN Lidan |
| collection | DOAJ |
| description | ObjectiveUsing New Zealand white rabbits as an animal model, the effectiveness and safety of a domestic porcine small intestinal submucosa (SIS) acellular matrix in repairing rabbit dura mater defects were evaluated by observing the physiological state, clinical manifestations, and pathological changes.MethodsForty-eight New Zealand white rabbits were randomly divided into a trial group (n=24) and a control group (n=24). The domestic SIS and commercially available materials (control) were implanted by surgery. The animals were sacrificed at 7, 30, 60, and 90 days after surgery for anatomical observation and histopathological analysis. All the animals were clinically observed during the study.ResultsBoth SIS materials were able to heal the dura mater 30 days after surgery. There were no obvious clinical abnormalities or significant differences in animal survival rates between the two groups. The morphological changes showing tissue reconstruction were similar at multiple time points, and no infectious inflammatory responses were observed following pathological histological examination in either group.ConclusionUnder the conditions of this trial, the repairing effect of the tested domestic SIS was similar to that ovserved in the control group, demonstrating that this type of SIS is an ideal material for dura mater repair. |
| first_indexed | 2024-04-13T13:35:57Z |
| format | Article |
| id | doaj.art-6de67db72fcb4753b9e1060b6ae587b9 |
| institution | Directory Open Access Journal |
| issn | 1674-5817 |
| language | zho |
| last_indexed | 2024-04-13T13:35:57Z |
| publishDate | 2022-02-01 |
| publisher | Editorial Office of Laboratory Animal and Comparative Medicine |
| record_format | Article |
| series | Shiyan dongwu yu bijiao yixue |
| spelling | doaj.art-6de67db72fcb4753b9e1060b6ae587b92022-12-22T02:44:47ZzhoEditorial Office of Laboratory Animal and Comparative MedicineShiyan dongwu yu bijiao yixue1674-58172022-02-01421364110.12300/j.issn.1674-5817.2021.0611674-5817（2022）01-0036-06Effectiveness and Safety of a Domestic Porcine Small Intestinal Submucosa Acellular Matrix in Rabbit Dura Mater RepairingSUN Lidan0YANG Feixia1ZHANG Di2CHEN Zeliang3ZHANG Zhihui4LI Yingjun5SHI Lijun6College of Animal Science and Veterinary Medicine , Shenyang Agricultural University, Shenyang 110866, ChinaBeijing Tonghe Litai Biotechnology Co., Ltd., Beijing 102609, ChinaBeijing Tonghe Litai Biotechnology Co., Ltd., Beijing 102609, ChinaCollege of Animal Science and Veterinary Medicine , Shenyang Agricultural University, Shenyang 110866, ChinaBeijing Tonghe Litai Biotechnology Co., Ltd., Beijing 102609, ChinaBeijing Tonghe Litai Biotechnology Co., Ltd., Beijing 102609, ChinaInstitute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaObjectiveUsing New Zealand white rabbits as an animal model, the effectiveness and safety of a domestic porcine small intestinal submucosa (SIS) acellular matrix in repairing rabbit dura mater defects were evaluated by observing the physiological state, clinical manifestations, and pathological changes.MethodsForty-eight New Zealand white rabbits were randomly divided into a trial group (n=24) and a control group (n=24). The domestic SIS and commercially available materials (control) were implanted by surgery. The animals were sacrificed at 7, 30, 60, and 90 days after surgery for anatomical observation and histopathological analysis. All the animals were clinically observed during the study.ResultsBoth SIS materials were able to heal the dura mater 30 days after surgery. There were no obvious clinical abnormalities or significant differences in animal survival rates between the two groups. The morphological changes showing tissue reconstruction were similar at multiple time points, and no infectious inflammatory responses were observed following pathological histological examination in either group.ConclusionUnder the conditions of this trial, the repairing effect of the tested domestic SIS was similar to that ovserved in the control group, demonstrating that this type of SIS is an ideal material for dura mater repair.https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.061porcine small intestinal submucosaacellular matrixdura materrabbit model |
| spellingShingle | SUN Lidan YANG Feixia ZHANG Di CHEN Zeliang ZHANG Zhihui LI Yingjun SHI Lijun Effectiveness and Safety of a Domestic Porcine Small Intestinal Submucosa Acellular Matrix in Rabbit Dura Mater Repairing Shiyan dongwu yu bijiao yixue porcine small intestinal submucosa acellular matrix dura mater rabbit model |
| title | Effectiveness and Safety of a Domestic Porcine Small Intestinal Submucosa Acellular Matrix in Rabbit Dura Mater Repairing |
| title_full | Effectiveness and Safety of a Domestic Porcine Small Intestinal Submucosa Acellular Matrix in Rabbit Dura Mater Repairing |
| title_fullStr | Effectiveness and Safety of a Domestic Porcine Small Intestinal Submucosa Acellular Matrix in Rabbit Dura Mater Repairing |
| title_full_unstemmed | Effectiveness and Safety of a Domestic Porcine Small Intestinal Submucosa Acellular Matrix in Rabbit Dura Mater Repairing |
| title_short | Effectiveness and Safety of a Domestic Porcine Small Intestinal Submucosa Acellular Matrix in Rabbit Dura Mater Repairing |
| title_sort | effectiveness and safety of a domestic porcine small intestinal submucosa acellular matrix in rabbit dura mater repairing |
| topic | porcine small intestinal submucosa acellular matrix dura mater rabbit model |
| url | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2021.061 |
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