Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs

Evaluation of pharmacokinetics underlies the collaborated usage of lamivudine and oxymatrine in beagle dogs

Combinational therapy of lamivudine and oxymatrine has been employed in the battle against hepatitis B virus in clinical setting. However, the pharmacokinetic behavior of the drug or active metabolism in intravenous/oral co-administration regime is poorly investigated. Herein, we evaluated the pharm...

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Bibliographic Details
Main Authors: Zhenbao Li, Lei Shang, Chang Liu, Panqin Ma, Chunnuan Wu, Wenjuan Zhang, Yinghua Sun, Yongjun Wang, Xiaohong Liu, Jin Sun
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Oxymatrine
Lamivudine
Matrine
Beagle dog
Intravenous/oral regime
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087616000131

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