Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice

Low Salt Delivery Triggers Autocrine Release of Prostaglandin E2 From the Aldosterone-Sensitive Distal Nephron in Familial Hyperkalemic Hypertension Mice

Aberrant activation of with-no-lysine kinase (WNK)-STE20/SPS1-related proline-alanine-rich protein kinase (SPAK) kinase signaling in the distal convoluted tubule (DCT) causes unbridled activation of the thiazide-sensitive sodium chloride cotransporter (NCC), leading to familial hyperkalemic hyperten...

Full description

Bibliographic Details
Main Authors: Ava M. Zapf, Paul R. Grimm, Lama Al-Qusairi, Eric Delpire, Paul A. Welling
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Physiology
Subjects:
distal convoluted tubule
ASDN
FHHt
prostaglandin E2
low salt
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.787323/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.787323/full

Similar Items