IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination

IL-17A expression by both T cells and non-T cells contribute to HSV-IL-2-induced CNS demyelination

Previously we reported that a recombinant HSV-1 expressing murine IL-2 (HSV-IL-2) causes CNS demyelination in different strains of mice and in a T cell-dependent manner. Since TH17 cells have been implicated in CNS pathology, in the present study, we looked into the effects of IL-17A-/- and three of...

Full description

Bibliographic Details
Main Authors: Satoshi Hirose, Shaohui Wang, Ujjaldeep Jaggi, Harry H. Matundan, Mihoko Kato, Xue-Ying Song, Sara J. Molesworth-Kenyon, Robert N. Lausch, Homayon Ghiasi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
Ocular infection
mouse
HSV-IL-2
knockout
IL17RA
IL17RC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1102486/full

Similar Items

Similar Items