The Influence of Periodontal Disease Treatment on 8-Hydroxy-Deoxyguanosine Concentrations in Saliva and Plasma of Chronic Periodontitis Patients
The 8-hydroxy-deoxyguanosine (8-OHdG) is one of the customary products of oxidized DNA. The purpose of this study was to compare salivary and plasma 8-OHdG concentrations in a group of chronic periodontitis patients to those measured in a group of patients with healthy periodontium, as well as to...
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2020-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/368719 |
| _version_ | 1797207005299998720 |
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| author | Tanja Veljović Milanko Đurić Ivana Gušić Jelena Mirnić Saša Čakić Aleksandra Maletin Snežana Brkić |
| author_facet | Tanja Veljović Milanko Đurić Ivana Gušić Jelena Mirnić Saša Čakić Aleksandra Maletin Snežana Brkić |
| author_sort | Tanja Veljović |
| collection | DOAJ |
| description | The 8-hydroxy-deoxyguanosine (8-OHdG) is one of the customary products of
oxidized DNA. The purpose of this study was to compare salivary and plasma 8-OHdG concentrations
in a group of chronic periodontitis patients to those measured in a group of patients with healthy
periodontium, as well as to determine the impact of periodontal therapy on 8-OHdG concentrations
in saliva and plasma in chronic periodontitis patients. The study sample comprised of 24 patients with
chronic periodontitis and 16 periodontally healthy individuals. Plaque index, gingival index, papilla
bleeding index, probing depth and clinical attachment level were indices used to determine patient
periodontal status. Salivary and plasma 8-OHdG concentrations were determined by ELISA method.
The salivary 8-OHdG concentration was statistically significantly higher in the group of periodontitis
patients compared to periodontally healthy subjects. After initial periodontal therapy, the 8-OHdG
concentration in saliva was significantly reduced in the periodontitis group (p=0.021). Differences in
plasma 8-OHdG concentrations between the two groups did not reach statistical significance and no
significant changes were noted in the periodontitis group following initial periodontal therapy. A
higher salivary 8-OHdG concentration reflects increased oxidative stress caused by periodontal disease.
Initial periodontal therapy may be helpful in reducing salivary 8-OHdG concentrations in
chronic periodontitis patients. |
| first_indexed | 2024-04-24T09:16:02Z |
| format | Article |
| id | doaj.art-6ded0652604e4395ae5bb1a65e07a894 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:16:02Z |
| publishDate | 2020-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-6ded0652604e4395ae5bb1a65e07a8942024-04-15T16:50:08ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512020-01-0159.4.61562110.20471/acc.2020.59.04.07The Influence of Periodontal Disease Treatment on 8-Hydroxy-Deoxyguanosine Concentrations in Saliva and Plasma of Chronic Periodontitis PatientsTanja Veljović0Milanko Đurić1Ivana Gušić2Jelena Mirnić3Saša Čakić4Aleksandra Maletin5Snežana Brkić6University of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; Department of Dentistry, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; Department of Dentistry, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity of Belgrade, Faculty of Dental Medicine, Department of Periodontology and Oral Medicine, Belgrade, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia; Department of Infectious Diseases, Clinical Centre of Vojvodina, Novi Sad, SerbiaThe 8-hydroxy-deoxyguanosine (8-OHdG) is one of the customary products of oxidized DNA. The purpose of this study was to compare salivary and plasma 8-OHdG concentrations in a group of chronic periodontitis patients to those measured in a group of patients with healthy periodontium, as well as to determine the impact of periodontal therapy on 8-OHdG concentrations in saliva and plasma in chronic periodontitis patients. The study sample comprised of 24 patients with chronic periodontitis and 16 periodontally healthy individuals. Plaque index, gingival index, papilla bleeding index, probing depth and clinical attachment level were indices used to determine patient periodontal status. Salivary and plasma 8-OHdG concentrations were determined by ELISA method. The salivary 8-OHdG concentration was statistically significantly higher in the group of periodontitis patients compared to periodontally healthy subjects. After initial periodontal therapy, the 8-OHdG concentration in saliva was significantly reduced in the periodontitis group (p=0.021). Differences in plasma 8-OHdG concentrations between the two groups did not reach statistical significance and no significant changes were noted in the periodontitis group following initial periodontal therapy. A higher salivary 8-OHdG concentration reflects increased oxidative stress caused by periodontal disease. Initial periodontal therapy may be helpful in reducing salivary 8-OHdG concentrations in chronic periodontitis patients.https://hrcak.srce.hr/file/368719DeoxyguanosineOxidative stressPeriodontal diseasesSalivaPlasma |
| spellingShingle | Tanja Veljović Milanko Đurić Ivana Gušić Jelena Mirnić Saša Čakić Aleksandra Maletin Snežana Brkić The Influence of Periodontal Disease Treatment on 8-Hydroxy-Deoxyguanosine Concentrations in Saliva and Plasma of Chronic Periodontitis Patients Acta Clinica Croatica Deoxyguanosine Oxidative stress Periodontal diseases Saliva Plasma |
| title | The Influence of Periodontal Disease Treatment on 8-Hydroxy-Deoxyguanosine Concentrations in Saliva and Plasma of Chronic Periodontitis Patients |
| title_full | The Influence of Periodontal Disease Treatment on 8-Hydroxy-Deoxyguanosine Concentrations in Saliva and Plasma of Chronic Periodontitis Patients |
| title_fullStr | The Influence of Periodontal Disease Treatment on 8-Hydroxy-Deoxyguanosine Concentrations in Saliva and Plasma of Chronic Periodontitis Patients |
| title_full_unstemmed | The Influence of Periodontal Disease Treatment on 8-Hydroxy-Deoxyguanosine Concentrations in Saliva and Plasma of Chronic Periodontitis Patients |
| title_short | The Influence of Periodontal Disease Treatment on 8-Hydroxy-Deoxyguanosine Concentrations in Saliva and Plasma of Chronic Periodontitis Patients |
| title_sort | influence of periodontal disease treatment on 8 hydroxy deoxyguanosine concentrations in saliva and plasma of chronic periodontitis patients |
| topic | Deoxyguanosine Oxidative stress Periodontal diseases Saliva Plasma |
| url | https://hrcak.srce.hr/file/368719 |
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