Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender
Abstract Introduction Agents that can be used for the treatment of neuropsychiatric lupus (NPSLE) are lacking in the therapeutic armamentarium. Belimumab is a monoclonal antibody targeting the B‐cell activating factor (BAFF) and is approved by the US Food and Drug Administration as an additional tre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Rheumatology & Autoimmunity |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rai2.12071 |
| _version_ | 1827913067855347712 |
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| author | Shuilian Yu Zhongjun Hou Zhiping Liu Zeying Lin Ling Zhong Qilin Yang Wenhui Huang |
| author_facet | Shuilian Yu Zhongjun Hou Zhiping Liu Zeying Lin Ling Zhong Qilin Yang Wenhui Huang |
| author_sort | Shuilian Yu |
| collection | DOAJ |
| description | Abstract Introduction Agents that can be used for the treatment of neuropsychiatric lupus (NPSLE) are lacking in the therapeutic armamentarium. Belimumab is a monoclonal antibody targeting the B‐cell activating factor (BAFF) and is approved by the US Food and Drug Administration as an additional treatment for systemic lupus erythematosus patients with persistent disease activity and lupus nephritis (LN); however, severe active central nervous system manifestations were excluded. Case Report We report on a treatment‐naïve LN patient with refractory NPSLE complicated with progressive posterior reversible encephalopathy syndrome (PRES) who was successfully treated via the combination of mycophenolate and belimumab, resulting in reversal of persistent headache and neuroradiologic manifestations. Conclusion Research on this topic could be relevant for identifying a possible correlation between BAFF and psychiatric NPSLE manifestations. |
| first_indexed | 2024-03-13T02:25:08Z |
| format | Article |
| id | doaj.art-6ded7585f18f4dd5a4d27d7d017166a0 |
| institution | Directory Open Access Journal |
| issn | 2767-1429 |
| language | English |
| last_indexed | 2024-03-13T02:25:08Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Rheumatology & Autoimmunity |
| spelling | doaj.art-6ded7585f18f4dd5a4d27d7d017166a02023-06-30T04:47:24ZengWileyRheumatology & Autoimmunity2767-14292023-06-013211511910.1002/rai2.12071Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offenderShuilian Yu0Zhongjun Hou1Zhiping Liu2Zeying Lin3Ling Zhong4Qilin Yang5Wenhui Huang6Department of Rheumatology, Second Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Radiology, Second Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong ChinaOphthalmic Center, Second Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Rheumatology, Second Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Pathology, Second Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Critical Care, Second Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong ChinaDepartment of Rheumatology, Second Affiliated Hospital Guangzhou Medical University Guangzhou Guangdong ChinaAbstract Introduction Agents that can be used for the treatment of neuropsychiatric lupus (NPSLE) are lacking in the therapeutic armamentarium. Belimumab is a monoclonal antibody targeting the B‐cell activating factor (BAFF) and is approved by the US Food and Drug Administration as an additional treatment for systemic lupus erythematosus patients with persistent disease activity and lupus nephritis (LN); however, severe active central nervous system manifestations were excluded. Case Report We report on a treatment‐naïve LN patient with refractory NPSLE complicated with progressive posterior reversible encephalopathy syndrome (PRES) who was successfully treated via the combination of mycophenolate and belimumab, resulting in reversal of persistent headache and neuroradiologic manifestations. Conclusion Research on this topic could be relevant for identifying a possible correlation between BAFF and psychiatric NPSLE manifestations.https://doi.org/10.1002/rai2.12071belimumablupus nephritisneuropsychiatric lupusposterior reversible encephalopathy syndrome |
| spellingShingle | Shuilian Yu Zhongjun Hou Zhiping Liu Zeying Lin Ling Zhong Qilin Yang Wenhui Huang Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender Rheumatology & Autoimmunity belimumab lupus nephritis neuropsychiatric lupus posterior reversible encephalopathy syndrome |
| title | Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender |
| title_full | Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender |
| title_fullStr | Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender |
| title_full_unstemmed | Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender |
| title_short | Belimumab shows promise in neuropsychiatric lupus: Another challenge to find the offender |
| title_sort | belimumab shows promise in neuropsychiatric lupus another challenge to find the offender |
| topic | belimumab lupus nephritis neuropsychiatric lupus posterior reversible encephalopathy syndrome |
| url | https://doi.org/10.1002/rai2.12071 |
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