Diagnosis of Pulmonary Infections Due to Endemic Fungi
Endemic mycoses including <i>Histoplasma</i>, <i>Blastomyces</i>, <i>Coccidioides</i>, <i>Paracoccidioides</i>, and <i>Talaromyces</i> are dimorphic fungi that can cause a variety of clinical manifestations, including respiratory infections...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/5/856 |
| _version_ | 1797534663387906048 |
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| author | Victoria Poplin Clarissa Smith Dominique Milsap Lauren Zabel Nathan C. Bahr |
| author_facet | Victoria Poplin Clarissa Smith Dominique Milsap Lauren Zabel Nathan C. Bahr |
| author_sort | Victoria Poplin |
| collection | DOAJ |
| description | Endemic mycoses including <i>Histoplasma</i>, <i>Blastomyces</i>, <i>Coccidioides</i>, <i>Paracoccidioides</i>, and <i>Talaromyces</i> are dimorphic fungi that can cause a variety of clinical manifestations, including respiratory infections. Their pulmonary presentations are variable, and diagnosis is often delayed as they can mimic other infectious and non-infectious causes of pulmonary disease. Delay in diagnosis can lead to unnecessary antibiotic use, repeat hospitalizations, and increased morbidity and mortality. The diagnosis of endemic fungal pulmonary infections often relies on multiple diagnostic tests including culture, tissue histopathology, antigen assays, and antibody assays. Due to the increased use of immunosuppressive agents and the widening geographic ranges where these infections are being found, the prevalence of endemic fungal infections is increasing. Physicians need to be aware of the clinical manifestations of pulmonary infections due to endemic fungal in order to ensure that the proper diagnostic work up is obtained promptly. A high index of suspicion is particularly important in patients with suspected pulmonary infections who have failed to improve despite antibiotics in the appropriate setting. We present a review diagnostic testing for pulmonary infections due to endemic mycoses. |
| first_indexed | 2024-03-10T11:33:41Z |
| format | Article |
| id | doaj.art-6dee5d0dc42b40a7b67d120ca3e27551 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T11:33:41Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6dee5d0dc42b40a7b67d120ca3e275512023-11-21T19:03:31ZengMDPI AGDiagnostics2075-44182021-05-0111585610.3390/diagnostics11050856Diagnosis of Pulmonary Infections Due to Endemic FungiVictoria Poplin0Clarissa Smith1Dominique Milsap2Lauren Zabel3Nathan C. Bahr4Department of Internal Medicine, Division of Infectious Diseases, University of Kansas, Kansas City, KS 66160, USADepartment of Internal Medicine, University of Kansas, Kansas City, KS 66160, USASchool of Medicine, University of Kansas, Kansas City, KS 66160, USASchool of Medicine, University of Kansas, Kansas City, KS 66160, USADepartment of Internal Medicine, Division of Infectious Diseases, University of Kansas, Kansas City, KS 66160, USAEndemic mycoses including <i>Histoplasma</i>, <i>Blastomyces</i>, <i>Coccidioides</i>, <i>Paracoccidioides</i>, and <i>Talaromyces</i> are dimorphic fungi that can cause a variety of clinical manifestations, including respiratory infections. Their pulmonary presentations are variable, and diagnosis is often delayed as they can mimic other infectious and non-infectious causes of pulmonary disease. Delay in diagnosis can lead to unnecessary antibiotic use, repeat hospitalizations, and increased morbidity and mortality. The diagnosis of endemic fungal pulmonary infections often relies on multiple diagnostic tests including culture, tissue histopathology, antigen assays, and antibody assays. Due to the increased use of immunosuppressive agents and the widening geographic ranges where these infections are being found, the prevalence of endemic fungal infections is increasing. Physicians need to be aware of the clinical manifestations of pulmonary infections due to endemic fungal in order to ensure that the proper diagnostic work up is obtained promptly. A high index of suspicion is particularly important in patients with suspected pulmonary infections who have failed to improve despite antibiotics in the appropriate setting. We present a review diagnostic testing for pulmonary infections due to endemic mycoses.https://www.mdpi.com/2075-4418/11/5/856endemic fungidiagnostic testshistoplasmosisblastomycosiscoccidioidomycosisparacoccidioidomycosis |
| spellingShingle | Victoria Poplin Clarissa Smith Dominique Milsap Lauren Zabel Nathan C. Bahr Diagnosis of Pulmonary Infections Due to Endemic Fungi Diagnostics endemic fungi diagnostic tests histoplasmosis blastomycosis coccidioidomycosis paracoccidioidomycosis |
| title | Diagnosis of Pulmonary Infections Due to Endemic Fungi |
| title_full | Diagnosis of Pulmonary Infections Due to Endemic Fungi |
| title_fullStr | Diagnosis of Pulmonary Infections Due to Endemic Fungi |
| title_full_unstemmed | Diagnosis of Pulmonary Infections Due to Endemic Fungi |
| title_short | Diagnosis of Pulmonary Infections Due to Endemic Fungi |
| title_sort | diagnosis of pulmonary infections due to endemic fungi |
| topic | endemic fungi diagnostic tests histoplasmosis blastomycosis coccidioidomycosis paracoccidioidomycosis |
| url | https://www.mdpi.com/2075-4418/11/5/856 |
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