Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation
In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbon–fluorine bond formation has become a landmark achievement in fluorine...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2013-11-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.9.287 |
| _version_ | 1818445006612987904 |
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| author | Grégory Landelle Armen Panossian Sergiy Pazenok Jean-Pierre Vors Frédéric R. Leroux |
| author_facet | Grégory Landelle Armen Panossian Sergiy Pazenok Jean-Pierre Vors Frédéric R. Leroux |
| author_sort | Grégory Landelle |
| collection | DOAJ |
| description | In the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbon–fluorine bond formation has become a landmark achievement in fluorine chemistry. This rapidly growing research field has been the subject of some excellent reviews. Our approach focuses exclusively on transition metal-catalyzed reactions that allow the introduction of –CFH2, –CF2H, –CnF2n+1 and –SCF3 groups onto sp² carbon atoms. Transformations are discussed according to the reaction-type and the metal employed. The review will not extend to conventional non-transition metal methods to these fluorinated groups. |
| first_indexed | 2024-12-14T19:24:58Z |
| format | Article |
| id | doaj.art-6def11311af04040bd27eb9d55d2f703 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-14T19:24:58Z |
| publishDate | 2013-11-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-6def11311af04040bd27eb9d55d2f7032022-12-21T22:50:12ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972013-11-01912476253610.3762/bjoc.9.2871860-5397-9-287Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolationGrégory Landelle0Armen Panossian1Sergiy Pazenok2Jean-Pierre Vors3Frédéric R. Leroux4CNRS-Université de Strasbourg, UMR 7509, SynCat, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, FranceCNRS-Université de Strasbourg, UMR 7509, SynCat, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, FranceBayer CropScience AG, Alfred-Nobel-Strasse 50, 40789 Monheim, GermanyBayer SAS, 14 impasse Pierre Baizet, 69263 Lyon, Cedex 09, FranceCNRS-Université de Strasbourg, UMR 7509, SynCat, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, FranceIn the last few years, transition metal-mediated reactions have joined the toolbox of chemists working in the field of fluorination for Life-Science oriented research. The successful execution of transition metal-catalyzed carbon–fluorine bond formation has become a landmark achievement in fluorine chemistry. This rapidly growing research field has been the subject of some excellent reviews. Our approach focuses exclusively on transition metal-catalyzed reactions that allow the introduction of –CFH2, –CF2H, –CnF2n+1 and –SCF3 groups onto sp² carbon atoms. Transformations are discussed according to the reaction-type and the metal employed. The review will not extend to conventional non-transition metal methods to these fluorinated groups.https://doi.org/10.3762/bjoc.9.287catalysiscross-couplingdifluoromethylationfluorinemonofluoromethylationorgano-fluorinetransition metaltrifluoromethylationtrifluoromethylthiolation |
| spellingShingle | Grégory Landelle Armen Panossian Sergiy Pazenok Jean-Pierre Vors Frédéric R. Leroux Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation Beilstein Journal of Organic Chemistry catalysis cross-coupling difluoromethylation fluorine monofluoromethylation organo-fluorine transition metal trifluoromethylation trifluoromethylthiolation |
| title | Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation |
| title_full | Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation |
| title_fullStr | Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation |
| title_full_unstemmed | Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation |
| title_short | Recent advances in transition metal-catalyzed Csp2-monofluoro-, difluoro-, perfluoromethylation and trifluoromethylthiolation |
| title_sort | recent advances in transition metal catalyzed csp2 monofluoro difluoro perfluoromethylation and trifluoromethylthiolation |
| topic | catalysis cross-coupling difluoromethylation fluorine monofluoromethylation organo-fluorine transition metal trifluoromethylation trifluoromethylthiolation |
| url | https://doi.org/10.3762/bjoc.9.287 |
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