A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms
Ongoing aortic wall degeneration and subsequent aneurysm exclusion failure are major concerns after an endovascular aneurysm repair with a stent-graft. An ideal solution would be a drug therapy that targets the aortic wall and inhibits wall degeneration. Here, we described a novel drug delivery syst...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/15/5538 |
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| author | Koichi Yoshimura Hiroki Aoki Chie Teruyama Masumi Iijima Hiromori Tsutsumi Shun’ichi Kuroda Kimikazu Hamano |
| author_facet | Koichi Yoshimura Hiroki Aoki Chie Teruyama Masumi Iijima Hiromori Tsutsumi Shun’ichi Kuroda Kimikazu Hamano |
| author_sort | Koichi Yoshimura |
| collection | DOAJ |
| description | Ongoing aortic wall degeneration and subsequent aneurysm exclusion failure are major concerns after an endovascular aneurysm repair with a stent-graft. An ideal solution would be a drug therapy that targets the aortic wall and inhibits wall degeneration. Here, we described a novel drug delivery system, which allowed repetitively charging a graft with therapeutic drugs and releasing them to the aortic wall in vivo. The system was composed of a targeted graft, which was labeled with a small target molecule, and the target-recognizing nanocarrier, which contained suitable drugs. We developed the targeted graft by decorating a biotinylated polyester graft with neutravidin. We created the target-recognizing nanocarrier by conjugating drug-containing liposomes with biotinylated bio-nanocapsules. We successfully demonstrated that the target-recognizing nanocarriers could bind to the targeted graft, both in vitro and in blood vessels of live mice. Moreover, the drug released from our drug delivery system reduced the expression of matrix metalloproteinase-9 in mouse aortas. Thus, this hybrid system represents a first step toward an adjuvant therapy that might improve the long-term outcome of endovascular aneurysm repair. |
| first_indexed | 2024-03-10T18:01:01Z |
| format | Article |
| id | doaj.art-6df11ea3547a447d8bf9edaf2be0a402 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:01:01Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6df11ea3547a447d8bf9edaf2be0a4022023-11-20T08:50:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012115553810.3390/ijms21155538A Novel Hybrid Drug Delivery System for Treatment of Aortic AneurysmsKoichi Yoshimura0Hiroki Aoki1Chie Teruyama2Masumi Iijima3Hiromori Tsutsumi4Shun’ichi Kuroda5Kimikazu Hamano6Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube 755-8505, JapanCardiovascular Research Institute, Kurume University, Kurume 830-0011, JapanGraduate School of Medicine, Yamaguchi University, Ube 755-8611, JapanDepartment of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo 156-8502, JapanDepartment of Applied Chemistry, Graduate School of Sciences and Technology for Innovation, Yamaguchi University, Ube 755-8611, JapanThe Institute of Scientific and Industrial Research, Osaka University, Ibaraki 567-0047, JapanDepartment of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube 755-8505, JapanOngoing aortic wall degeneration and subsequent aneurysm exclusion failure are major concerns after an endovascular aneurysm repair with a stent-graft. An ideal solution would be a drug therapy that targets the aortic wall and inhibits wall degeneration. Here, we described a novel drug delivery system, which allowed repetitively charging a graft with therapeutic drugs and releasing them to the aortic wall in vivo. The system was composed of a targeted graft, which was labeled with a small target molecule, and the target-recognizing nanocarrier, which contained suitable drugs. We developed the targeted graft by decorating a biotinylated polyester graft with neutravidin. We created the target-recognizing nanocarrier by conjugating drug-containing liposomes with biotinylated bio-nanocapsules. We successfully demonstrated that the target-recognizing nanocarriers could bind to the targeted graft, both in vitro and in blood vessels of live mice. Moreover, the drug released from our drug delivery system reduced the expression of matrix metalloproteinase-9 in mouse aortas. Thus, this hybrid system represents a first step toward an adjuvant therapy that might improve the long-term outcome of endovascular aneurysm repair.https://www.mdpi.com/1422-0067/21/15/5538drug delivery systemaortic aneurysmendovascular aneurysm repairbio-nanocapsule |
| spellingShingle | Koichi Yoshimura Hiroki Aoki Chie Teruyama Masumi Iijima Hiromori Tsutsumi Shun’ichi Kuroda Kimikazu Hamano A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms International Journal of Molecular Sciences drug delivery system aortic aneurysm endovascular aneurysm repair bio-nanocapsule |
| title | A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms |
| title_full | A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms |
| title_fullStr | A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms |
| title_full_unstemmed | A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms |
| title_short | A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms |
| title_sort | novel hybrid drug delivery system for treatment of aortic aneurysms |
| topic | drug delivery system aortic aneurysm endovascular aneurysm repair bio-nanocapsule |
| url | https://www.mdpi.com/1422-0067/21/15/5538 |
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