The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis
Abstract Background Pulmonary hypertension (PH) is a known co-morbidity in West Highland white terriers (WHWTs) affected with canine idiopathic pulmonary fibrosis (CIPF). The pulmonary vein-to-right pulmonary artery ratio (PV/PA) has recently been described for the detection of pre-capillary PH in d...
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| Format: | Article |
| Language: | English |
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BMC
2021-04-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-021-02879-w |
| _version_ | 1818385559207280640 |
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| author | Elodie Roels Aline Fastrès Anne-Christine Merveille Géraldine Bolen Erik Teske Cécile Clercx Kathleen Mc Entee |
| author_facet | Elodie Roels Aline Fastrès Anne-Christine Merveille Géraldine Bolen Erik Teske Cécile Clercx Kathleen Mc Entee |
| author_sort | Elodie Roels |
| collection | DOAJ |
| description | Abstract Background Pulmonary hypertension (PH) is a known co-morbidity in West Highland white terriers (WHWTs) affected with canine idiopathic pulmonary fibrosis (CIPF). The pulmonary vein-to-right pulmonary artery ratio (PV/PA) has recently been described for the detection of pre-capillary PH in dogs. The objective of the present study was to estimate the prevalence of PH at diagnostic, in WHWTs affected with CIPF, by using PV/PA, in comparison with a group of healthy breed-matched controls (CTRLs). Additional study objective was to explore whether the presence of PH at initial diagnosis of CIPF impacted survival time in dogs treated with sildenafil. Results Twenty-five client-owned WHWTs presented with CIPF and 19 CTRLs were included in the study. PV/PA in either two-dimensional mode (2D) or time-motion mode or both were measured from cineloops in each dog. Dogs were classified according to PV/PA value into non/mild PH (PV/PA measured in 2D ≥ 0.7) or moderate/severe PH (PV/PA < 0.7). Survival data of WHWTs affected with CIPF were extracted from medical record to assess association between presence of PH at diagnosis and outcome. 60 % overall prevalence for moderate/severe PH was estimated in this cohort of WHWTs presented with CIPF vs. 5 % in CTRLS (P = 0.0002). The presence of moderate/severe PH at initial presentation was not associated with survival. Conclusions Results of the present study confirm a high prevalence of PH at diagnosis in WHWTs affected with CIPF and highlight the utility of PV/PA as a non-invasive surrogate for assessment of PH in this population. |
| first_indexed | 2024-12-14T03:40:05Z |
| format | Article |
| id | doaj.art-6df407d477d0432d8d19b8945e9e053c |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-12-14T03:40:05Z |
| publishDate | 2021-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-6df407d477d0432d8d19b8945e9e053c2022-12-21T23:18:30ZengBMCBMC Veterinary Research1746-61482021-04-011711710.1186/s12917-021-02879-wThe prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosisElodie Roels0Aline Fastrès1Anne-Christine Merveille2Géraldine Bolen3Erik Teske4Cécile Clercx5Kathleen Mc Entee6Department of Internal Medicine, Pride Veterinary CentreDepartment of Clinical Sciences, Faculty of Veterinary Medicine, FARAH, University of LiegeDepartment of Clinical Sciences, Faculty of Veterinary Medicine, FARAH, University of LiegeDepartment of Clinical Sciences, Faculty of Veterinary Medicine, FARAH, University of LiegeDepartment of Clinical Sciences of Companion Animals, Faculty of Medicine, Utrecht UniversityDepartment of Clinical Sciences, Faculty of Veterinary Medicine, FARAH, University of LiegeLaboratory of Physiology and Pharmacology, Faculty of Medicine, Université Libre de BruxellesAbstract Background Pulmonary hypertension (PH) is a known co-morbidity in West Highland white terriers (WHWTs) affected with canine idiopathic pulmonary fibrosis (CIPF). The pulmonary vein-to-right pulmonary artery ratio (PV/PA) has recently been described for the detection of pre-capillary PH in dogs. The objective of the present study was to estimate the prevalence of PH at diagnostic, in WHWTs affected with CIPF, by using PV/PA, in comparison with a group of healthy breed-matched controls (CTRLs). Additional study objective was to explore whether the presence of PH at initial diagnosis of CIPF impacted survival time in dogs treated with sildenafil. Results Twenty-five client-owned WHWTs presented with CIPF and 19 CTRLs were included in the study. PV/PA in either two-dimensional mode (2D) or time-motion mode or both were measured from cineloops in each dog. Dogs were classified according to PV/PA value into non/mild PH (PV/PA measured in 2D ≥ 0.7) or moderate/severe PH (PV/PA < 0.7). Survival data of WHWTs affected with CIPF were extracted from medical record to assess association between presence of PH at diagnosis and outcome. 60 % overall prevalence for moderate/severe PH was estimated in this cohort of WHWTs presented with CIPF vs. 5 % in CTRLS (P = 0.0002). The presence of moderate/severe PH at initial presentation was not associated with survival. Conclusions Results of the present study confirm a high prevalence of PH at diagnosis in WHWTs affected with CIPF and highlight the utility of PV/PA as a non-invasive surrogate for assessment of PH in this population.https://doi.org/10.1186/s12917-021-02879-wDogCardiac diseaseEchocardiographyPulmonary arterial pressureTricuspid regurgitation |
| spellingShingle | Elodie Roels Aline Fastrès Anne-Christine Merveille Géraldine Bolen Erik Teske Cécile Clercx Kathleen Mc Entee The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis BMC Veterinary Research Dog Cardiac disease Echocardiography Pulmonary arterial pressure Tricuspid regurgitation |
| title | The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis |
| title_full | The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis |
| title_fullStr | The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis |
| title_full_unstemmed | The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis |
| title_short | The prevalence of pulmonary hypertension assessed using the pulmonary vein‐to‐right pulmonary artery ratio and its association with survival in West Highland white terriers with canine idiopathic pulmonary fibrosis |
| title_sort | prevalence of pulmonary hypertension assessed using the pulmonary vein to right pulmonary artery ratio and its association with survival in west highland white terriers with canine idiopathic pulmonary fibrosis |
| topic | Dog Cardiac disease Echocardiography Pulmonary arterial pressure Tricuspid regurgitation |
| url | https://doi.org/10.1186/s12917-021-02879-w |
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