Arachidonic acid inhibits lipogenic gene expression in 3T3-L1 adipocytes through a prostanoid pathway

Arachidonic acid inhibits lipogenic gene expression in 3T3-L1 adipocytes through a prostanoid pathway

This report examines the effect of polyunsaturated fatty acids (PUFA) on lipogenic gene expression in cultured 3T3-L1 adipocytes. Arachidonic acid (20:4, n–6) and eicosapentaenoic acid (20:5, n–3) suppressed mRNAs encoding fatty acid synthase (FAS) and S14, but had no effect on β-actin. Using a clon...

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Bibliographic Details
Main Authors:	Michelle K. Mater, David Pan, W.G. Bergen, Donald B. Jump
Format:	Article
Language:	English
Published:	Elsevier 1998-07-01
Series:	Journal of Lipid Research
Subjects:	adipocytes polyunsaturated fatty acids arachidonic acid transcription PGE2 inositol phosphate/calcium
Online Access:	http://www.sciencedirect.com/science/article/pii/S002222752032513X

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