Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting
Abstract Single-atom catalysts (SACs) have attracted interest in photodynamic therapy (PDT), while they are normally limited by the side effects on normal tissues and the interference from the Tumor Microenvironment (TME). Here we show a TME-activated in situ synthesis of SACs for efficient tumor-sp...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46987-1 |
| _version_ | 1797219738996178944 |
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| author | Yiyan Yin Xiyang Ge Jin Ouyang Na Na |
| author_facet | Yiyan Yin Xiyang Ge Jin Ouyang Na Na |
| author_sort | Yiyan Yin |
| collection | DOAJ |
| description | Abstract Single-atom catalysts (SACs) have attracted interest in photodynamic therapy (PDT), while they are normally limited by the side effects on normal tissues and the interference from the Tumor Microenvironment (TME). Here we show a TME-activated in situ synthesis of SACs for efficient tumor-specific water-based PDT. Upon reduction by upregulated GSH in TME, C3N4-Mn SACs are obtained in TME with Mn atomically coordinated into the cavity of C3N4 nanosheets. This in situ synthesis overcomes toxicity from random distribution and catalyst release in healthy tissues. Based on the Ligand-to-Metal charge transfer (LMCT) process, C3N4-Mn SACs exhibit enhanced absorption in the red-light region. Thereby, a water-splitting process is induced by C3N4-Mn SACs under 660 nm irradiation, which initiates the O2-independent generation of highly toxic hydroxyl radical (·OH) for cancer-specific PDT. Subsequently, the ·OH-initiated lipid peroxidation process is demonstrated to devote effective cancer cell death. The in situ synthesized SACs facilitate the precise cancer-specific conversion of inert H2O to reactive ·OH, which facilitates efficient cancer therapy in female mice. This strategy achieves efficient and precise cancer therapy, not only avoiding the side effects on normal tissues but also overcoming tumor hypoxia. |
| first_indexed | 2024-04-24T12:38:26Z |
| format | Article |
| id | doaj.art-6df5b90f0b644356b5d75d1126c57f27 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-24T12:38:26Z |
| publishDate | 2024-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6df5b90f0b644356b5d75d1126c57f272024-04-07T11:23:14ZengNature PortfolioNature Communications2041-17232024-04-0115111610.1038/s41467-024-46987-1Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splittingYiyan Yin0Xiyang Ge1Jin Ouyang2Na Na3Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityDepartment of Chemistry, College of Arts and Sciences, Beijing Normal University at ZhuhaiKey Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal UniversityAbstract Single-atom catalysts (SACs) have attracted interest in photodynamic therapy (PDT), while they are normally limited by the side effects on normal tissues and the interference from the Tumor Microenvironment (TME). Here we show a TME-activated in situ synthesis of SACs for efficient tumor-specific water-based PDT. Upon reduction by upregulated GSH in TME, C3N4-Mn SACs are obtained in TME with Mn atomically coordinated into the cavity of C3N4 nanosheets. This in situ synthesis overcomes toxicity from random distribution and catalyst release in healthy tissues. Based on the Ligand-to-Metal charge transfer (LMCT) process, C3N4-Mn SACs exhibit enhanced absorption in the red-light region. Thereby, a water-splitting process is induced by C3N4-Mn SACs under 660 nm irradiation, which initiates the O2-independent generation of highly toxic hydroxyl radical (·OH) for cancer-specific PDT. Subsequently, the ·OH-initiated lipid peroxidation process is demonstrated to devote effective cancer cell death. The in situ synthesized SACs facilitate the precise cancer-specific conversion of inert H2O to reactive ·OH, which facilitates efficient cancer therapy in female mice. This strategy achieves efficient and precise cancer therapy, not only avoiding the side effects on normal tissues but also overcoming tumor hypoxia.https://doi.org/10.1038/s41467-024-46987-1 |
| spellingShingle | Yiyan Yin Xiyang Ge Jin Ouyang Na Na Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting Nature Communications |
| title | Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting |
| title_full | Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting |
| title_fullStr | Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting |
| title_full_unstemmed | Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting |
| title_short | Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting |
| title_sort | tumor activated in situ synthesis of single atom catalysts for o2 independent photodynamic therapy based on water splitting |
| url | https://doi.org/10.1038/s41467-024-46987-1 |
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