A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
The limited size of some neuronal types and their entangled environment renders it difficult to study their transcription regulation. Here the authors present a comparative analysis of histone modifications and transcription in dopaminergic and serotonergic neurons and embryonic neural progenitors....
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2018-03-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-03538-9 |
_version_ | 1818835021940654080 |
---|---|
author | Erik Södersten Konstantinos Toskas Vilma Rraklli Katarina Tiklova Åsa K. Björklund Markus Ringnér Thomas Perlmann Johan Holmberg |
author_facet | Erik Södersten Konstantinos Toskas Vilma Rraklli Katarina Tiklova Åsa K. Björklund Markus Ringnér Thomas Perlmann Johan Holmberg |
author_sort | Erik Södersten |
collection | DOAJ |
description | The limited size of some neuronal types and their entangled environment renders it difficult to study their transcription regulation. Here the authors present a comparative analysis of histone modifications and transcription in dopaminergic and serotonergic neurons and embryonic neural progenitors. |
first_indexed | 2024-12-19T02:44:06Z |
format | Article |
id | doaj.art-6df7c45a61984546bf5cda6b2f25f8ed |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-12-19T02:44:06Z |
publishDate | 2018-03-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-6df7c45a61984546bf5cda6b2f25f8ed2022-12-21T20:39:01ZengNature PortfolioNature Communications2041-17232018-03-019111610.1038/s41467-018-03538-9A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neuronsErik Södersten0Konstantinos Toskas1Vilma Rraklli2Katarina Tiklova3Åsa K. Björklund4Markus Ringnér5Thomas Perlmann6Johan Holmberg7Department of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska InstitutetDepartment of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska InstitutetDepartment of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska InstitutetDepartment of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska InstitutetDepartment for Cell and Molecular Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Uppsala UniversityDepartment of Biology, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Lund UniversityDepartment of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska InstitutetDepartment of Cell and Molecular Biology, Ludwig Institute for Cancer Research, Karolinska InstitutetThe limited size of some neuronal types and their entangled environment renders it difficult to study their transcription regulation. Here the authors present a comparative analysis of histone modifications and transcription in dopaminergic and serotonergic neurons and embryonic neural progenitors.https://doi.org/10.1038/s41467-018-03538-9 |
spellingShingle | Erik Södersten Konstantinos Toskas Vilma Rraklli Katarina Tiklova Åsa K. Björklund Markus Ringnér Thomas Perlmann Johan Holmberg A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons Nature Communications |
title | A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons |
title_full | A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons |
title_fullStr | A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons |
title_full_unstemmed | A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons |
title_short | A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons |
title_sort | comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons |
url | https://doi.org/10.1038/s41467-018-03538-9 |
work_keys_str_mv | AT eriksodersten acomprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT konstantinostoskas acomprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT vilmarraklli acomprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT katarinatiklova acomprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT asakbjorklund acomprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT markusringner acomprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT thomasperlmann acomprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT johanholmberg acomprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT eriksodersten comprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT konstantinostoskas comprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT vilmarraklli comprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT katarinatiklova comprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT asakbjorklund comprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT markusringner comprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT thomasperlmann comprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons AT johanholmberg comprehensivemapcouplinghistonemodificationswithgeneregulationinadultdopaminergicandserotonergicneurons |