T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy
Abstract Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic ne...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-11-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51653 |
| _version_ | 1797627604788838400 |
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| author | Colin Denis Kevin Dabbs Veena A. Nair Jedidiah Mathis Dace N. Almane Akshayaa Lakshmanan Andrew Nencka Rasmus M. Birn Lisa Conant Colin Humphries Elizabeth Felton Manoj Raghavan Edgar A. DeYoe Jeffrey R. Binder Bruce Hermann Vivek Prabhakaran Barbara B. Bendlin Mary E. Meyerand Mélanie Boly Aaron F. Struck |
| author_facet | Colin Denis Kevin Dabbs Veena A. Nair Jedidiah Mathis Dace N. Almane Akshayaa Lakshmanan Andrew Nencka Rasmus M. Birn Lisa Conant Colin Humphries Elizabeth Felton Manoj Raghavan Edgar A. DeYoe Jeffrey R. Binder Bruce Hermann Vivek Prabhakaran Barbara B. Bendlin Mary E. Meyerand Mélanie Boly Aaron F. Struck |
| author_sort | Colin Denis |
| collection | DOAJ |
| description | Abstract Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age‐matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group‐level aberrations in overall myelin content or myelin changes through time in TLE. |
| first_indexed | 2024-03-11T10:27:39Z |
| format | Article |
| id | doaj.art-6df92d1825a94807954e9d689ee372fc |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-03-11T10:27:39Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-6df92d1825a94807954e9d689ee372fc2023-11-15T11:57:14ZengWileyAnnals of Clinical and Translational Neurology2328-95032023-11-0110112149215410.1002/acn3.51653T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsyColin Denis0Kevin Dabbs1Veena A. Nair2Jedidiah Mathis3Dace N. Almane4Akshayaa Lakshmanan5Andrew Nencka6Rasmus M. Birn7Lisa Conant8Colin Humphries9Elizabeth Felton10Manoj Raghavan11Edgar A. DeYoe12Jeffrey R. Binder13Bruce Hermann14Vivek Prabhakaran15Barbara B. Bendlin16Mary E. Meyerand17Mélanie Boly18Aaron F. Struck19Department of Neurology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Neurology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Radiology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Radiology Medical College of Wisconsin Milwaukee Wisconsin USADepartment of Neurology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Neurology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Radiology Medical College of Wisconsin Milwaukee Wisconsin USADepartment of Radiology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Neurology Medical College of Wisconsin Milwaukee Wisconsin USADepartment of Neurology Medical College of Wisconsin Milwaukee Wisconsin USADepartment of Neurology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Neurology Medical College of Wisconsin Milwaukee Wisconsin USADepartment of Radiology Medical College of Wisconsin Milwaukee Wisconsin USADepartment of Neurology Medical College of Wisconsin Milwaukee Wisconsin USADepartment of Neurology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Radiology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medical Physics University of Wisconsin‐Madison Madison Wisconsin USADepartment of Neurology University of Wisconsin‐Madison Madison Wisconsin USADepartment of Neurology University of Wisconsin‐Madison Madison Wisconsin USAAbstract Short‐range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age‐matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group‐level aberrations in overall myelin content or myelin changes through time in TLE.https://doi.org/10.1002/acn3.51653 |
| spellingShingle | Colin Denis Kevin Dabbs Veena A. Nair Jedidiah Mathis Dace N. Almane Akshayaa Lakshmanan Andrew Nencka Rasmus M. Birn Lisa Conant Colin Humphries Elizabeth Felton Manoj Raghavan Edgar A. DeYoe Jeffrey R. Binder Bruce Hermann Vivek Prabhakaran Barbara B. Bendlin Mary E. Meyerand Mélanie Boly Aaron F. Struck T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy Annals of Clinical and Translational Neurology |
| title | T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy |
| title_full | T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy |
| title_fullStr | T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy |
| title_full_unstemmed | T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy |
| title_short | T1−/T2‐weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy |
| title_sort | t1 t2 weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy |
| url | https://doi.org/10.1002/acn3.51653 |
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