Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients
Abstract Background Some factors related to diet are known to be involved in the progression of atherosclerosis in humans. Methods The relationship between plasma fatty acid (FA) levels and the severity of coronary artery disease (CAD), evaluated by Gensini score (GS), was investigated in CAD Tunisi...
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-017-0538-y |
| _version_ | 1819070984822456320 |
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| author | Samia Hadj Ahmed Nadia Kaoubaa Wafa Kharroubi Amira Zarrouk Mohamed Fadhel Najjar Fathi Batbout Habib Gamra Gerard Lizard Mohamed Hammami |
| author_facet | Samia Hadj Ahmed Nadia Kaoubaa Wafa Kharroubi Amira Zarrouk Mohamed Fadhel Najjar Fathi Batbout Habib Gamra Gerard Lizard Mohamed Hammami |
| author_sort | Samia Hadj Ahmed |
| collection | DOAJ |
| description | Abstract Background Some factors related to diet are known to be involved in the progression of atherosclerosis in humans. Methods The relationship between plasma fatty acid (FA) levels and the severity of coronary artery disease (CAD), evaluated by Gensini score (GS), was investigated in CAD Tunisian patients compared to controls. Lipid profiles were analyzed, GS was calculated in CAD and non-CAD patients and compared to controls. Results CAD patients showed an alteration of conventional lipid parameters. In fact, a significant increase of plasmatic triglycerides (TG) level, atherogenic lipid ratios (TC/HDL-C,TG/HDL-C, LDL-C/HDL-C); and ApoB/ApoA1 was observed in the CAD group comparatively to controls (p < 0.001). Gensini score was showed to be a good indicator to evaluate cholesterol metabolism disorders associated with HDL-C since a negative association was found between HDL-C levels and GS for the two groups of patients. In addition, in the relation with FA and classes of FA, a negative association was found as expected, between Gensini score and total MUFA, PUFA n-3, total PUFA, GLA, DGLA and DHA. Furthermore, a positive association with stearic and erucic acid was found. Suggests that, GS is also a good indicator to evaluate FA metabolic disorders. Higher elongation index and modifications of desaturation index (D5D, D6D and D9D) were observed in patients compared to controls, supporting FA metabolism modifications. Conclusions In conclusion, although that Tunisian population appears to follow the Mediterranean diet, variations of plasmatic FA levels and desaturase activities in CAD patients highlights an alteration of FA metabolism and suggests an important implication of certain FA in the development of atherosclerosis. |
| first_indexed | 2024-12-21T17:14:37Z |
| format | Article |
| id | doaj.art-6df93125653f4827b0b771022f7c55a2 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-21T17:14:37Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-6df93125653f4827b0b771022f7c55a22022-12-21T18:56:19ZengBMCLipids in Health and Disease1476-511X2017-08-0116111310.1186/s12944-017-0538-yAssociation of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patientsSamia Hadj Ahmed0Nadia Kaoubaa1Wafa Kharroubi2Amira Zarrouk3Mohamed Fadhel Najjar4Fathi Batbout5Habib Gamra6Gerard Lizard7Mohamed Hammami8Faculty of Medicine, Research Laboratory LR12ES05, Lab-NAFS ‘Nutrition - Functional Food & Vascular Health’, University of Monastir (Tunisia)Faculty of Medicine, Research Laboratory LR12ES05, Lab-NAFS ‘Nutrition - Functional Food & Vascular Health’, University of Monastir (Tunisia)Faculty of Medicine, Research Laboratory LR12ES05, Lab-NAFS ‘Nutrition - Functional Food & Vascular Health’, University of Monastir (Tunisia)Faculty of Medicine, Research Laboratory LR12ES05, Lab-NAFS ‘Nutrition - Functional Food & Vascular Health’, University of Monastir (Tunisia)Biochemistry Department CHU Fattouma Bourguiba Monastir- TunisiaCardiology Department CHU Fattouma Bourguiba Monastir- TunisiaCardiology Department CHU Fattouma Bourguiba Monastir- TunisiaTeam ‘Biochemistry of Peroxisome, Inflammation and Lipid Metabolism’ EA 7270 /University of Bourgogne-Franche Comté / INSERMFaculty of Medicine, Research Laboratory LR12ES05, Lab-NAFS ‘Nutrition - Functional Food & Vascular Health’, University of Monastir (Tunisia)Abstract Background Some factors related to diet are known to be involved in the progression of atherosclerosis in humans. Methods The relationship between plasma fatty acid (FA) levels and the severity of coronary artery disease (CAD), evaluated by Gensini score (GS), was investigated in CAD Tunisian patients compared to controls. Lipid profiles were analyzed, GS was calculated in CAD and non-CAD patients and compared to controls. Results CAD patients showed an alteration of conventional lipid parameters. In fact, a significant increase of plasmatic triglycerides (TG) level, atherogenic lipid ratios (TC/HDL-C,TG/HDL-C, LDL-C/HDL-C); and ApoB/ApoA1 was observed in the CAD group comparatively to controls (p < 0.001). Gensini score was showed to be a good indicator to evaluate cholesterol metabolism disorders associated with HDL-C since a negative association was found between HDL-C levels and GS for the two groups of patients. In addition, in the relation with FA and classes of FA, a negative association was found as expected, between Gensini score and total MUFA, PUFA n-3, total PUFA, GLA, DGLA and DHA. Furthermore, a positive association with stearic and erucic acid was found. Suggests that, GS is also a good indicator to evaluate FA metabolic disorders. Higher elongation index and modifications of desaturation index (D5D, D6D and D9D) were observed in patients compared to controls, supporting FA metabolism modifications. Conclusions In conclusion, although that Tunisian population appears to follow the Mediterranean diet, variations of plasmatic FA levels and desaturase activities in CAD patients highlights an alteration of FA metabolism and suggests an important implication of certain FA in the development of atherosclerosis.http://link.springer.com/article/10.1186/s12944-017-0538-yFatty acid profileCoronary artery diseaseGensini scoreDesaturation index |
| spellingShingle | Samia Hadj Ahmed Nadia Kaoubaa Wafa Kharroubi Amira Zarrouk Mohamed Fadhel Najjar Fathi Batbout Habib Gamra Gerard Lizard Mohamed Hammami Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients Lipids in Health and Disease Fatty acid profile Coronary artery disease Gensini score Desaturation index |
| title | Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients |
| title_full | Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients |
| title_fullStr | Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients |
| title_full_unstemmed | Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients |
| title_short | Association of plasma fatty acid alteration with the severity of coronary artery disease lesions in Tunisian patients |
| title_sort | association of plasma fatty acid alteration with the severity of coronary artery disease lesions in tunisian patients |
| topic | Fatty acid profile Coronary artery disease Gensini score Desaturation index |
| url | http://link.springer.com/article/10.1186/s12944-017-0538-y |
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