Neuropharmacological and Antidiarrheal Potentials of <i>Duabanga grandiflora</i> (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules
<i>Duabanga grandiflora</i> (DC.) Walp. is an ethnomedicinally significant plant used to treat various illnesses, but there is little scientific evidence to support its use. This study explored the pharmacological activities of methanol extract of <i>D. grandiflora</i> stem b...
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MDPI AG
2022-05-01
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| Online Access: | https://www.mdpi.com/1467-3045/44/5/159 |
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| author | Israt Jahan Mohammad Forhad Khan Mohammed Abu Sayeed Laiba Arshad Md. Amjad Hossen Md. Jakaria Duygu Ağagündüz Md. Areeful Haque Raffaele Capasso |
| author_facet | Israt Jahan Mohammad Forhad Khan Mohammed Abu Sayeed Laiba Arshad Md. Amjad Hossen Md. Jakaria Duygu Ağagündüz Md. Areeful Haque Raffaele Capasso |
| author_sort | Israt Jahan |
| collection | DOAJ |
| description | <i>Duabanga grandiflora</i> (DC.) Walp. is an ethnomedicinally significant plant used to treat various illnesses, but there is little scientific evidence to support its use. This study explored the pharmacological activities of methanol extract of <i>D. grandiflora</i> stem barks (MEDG) through in vivo approaches in Swiss albino mice and a computer-aided molecular approach. The forced swimming test (FST), tail suspension test (TST), elevated plus maze (EPM), and hole board test (HBT) were used to determine anti-depressant and anxiolytic activity in experimental mice. In addition, anti-diarrheal studies were performed using castor oil-induced diarrhea, castor oil-induced enter pooling, and the charcoal-induced gastrointestinal motility test. MEDG showed substantial depletions in the immobility times in both FST and TST after treatment with the MEDG extract, whereas moderate anxiolytic activity was manifested at a higher dose (400 mg/kg) compared with the control. Correspondingly, MEDG extract revealed a significant reduction in wet feces and decreased the small intestinal transit of charcoal meal in castor oil-induced diarrhea and charcoal-induced gastrointestinal motility test. In the computer-aided molecular approaches, vanillin displayed a promising binding score for both anxiolytic and anti-diarrheal activities, while duabanganal C showed a promising score for the anti-depressant activity. The present experimental findings along with a computer-aided model conclude that MEDG could be a possible Phyto therapeutic agent with potential anti-depressant, anxiolytic and anti-diarrheal activity. |
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| language | English |
| last_indexed | 2024-03-10T03:05:46Z |
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| series | Current Issues in Molecular Biology |
| spelling | doaj.art-6dfb5cb8b3044de9ad8cd7750a5217d92023-11-23T10:32:34ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-05-014452335234910.3390/cimb44050159Neuropharmacological and Antidiarrheal Potentials of <i>Duabanga grandiflora</i> (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead MoleculesIsrat Jahan0Mohammad Forhad Khan1Mohammed Abu Sayeed2Laiba Arshad3Md. Amjad Hossen4Md. Jakaria5Duygu Ağagündüz6Md. Areeful Haque7Raffaele Capasso8Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, BangladeshDepartment of Pharmacy, International Islamic University Chittagong, Chittagong 4318, BangladeshDepartment of Pharmacy, International Islamic University Chittagong, Chittagong 4318, BangladeshDepartment of Pharmacy, Forman Christian College (A Chartered University), Lahore 54600, PakistanDepartment of Pharmacy, International Islamic University Chittagong, Chittagong 4318, BangladeshThe Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3052, AustraliaDepartment of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Emek, Ankara 06490, TurkeyDepartment of Pharmacy, International Islamic University Chittagong, Chittagong 4318, BangladeshDepartment of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy<i>Duabanga grandiflora</i> (DC.) Walp. is an ethnomedicinally significant plant used to treat various illnesses, but there is little scientific evidence to support its use. This study explored the pharmacological activities of methanol extract of <i>D. grandiflora</i> stem barks (MEDG) through in vivo approaches in Swiss albino mice and a computer-aided molecular approach. The forced swimming test (FST), tail suspension test (TST), elevated plus maze (EPM), and hole board test (HBT) were used to determine anti-depressant and anxiolytic activity in experimental mice. In addition, anti-diarrheal studies were performed using castor oil-induced diarrhea, castor oil-induced enter pooling, and the charcoal-induced gastrointestinal motility test. MEDG showed substantial depletions in the immobility times in both FST and TST after treatment with the MEDG extract, whereas moderate anxiolytic activity was manifested at a higher dose (400 mg/kg) compared with the control. Correspondingly, MEDG extract revealed a significant reduction in wet feces and decreased the small intestinal transit of charcoal meal in castor oil-induced diarrhea and charcoal-induced gastrointestinal motility test. In the computer-aided molecular approaches, vanillin displayed a promising binding score for both anxiolytic and anti-diarrheal activities, while duabanganal C showed a promising score for the anti-depressant activity. The present experimental findings along with a computer-aided model conclude that MEDG could be a possible Phyto therapeutic agent with potential anti-depressant, anxiolytic and anti-diarrheal activity.https://www.mdpi.com/1467-3045/44/5/159<i>Duabanga grandiflora</i> (DC.) Walp.anti-depressantanxiolyticanti-diarrhealvanillin |
| spellingShingle | Israt Jahan Mohammad Forhad Khan Mohammed Abu Sayeed Laiba Arshad Md. Amjad Hossen Md. Jakaria Duygu Ağagündüz Md. Areeful Haque Raffaele Capasso Neuropharmacological and Antidiarrheal Potentials of <i>Duabanga grandiflora</i> (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules Current Issues in Molecular Biology <i>Duabanga grandiflora</i> (DC.) Walp. anti-depressant anxiolytic anti-diarrheal vanillin |
| title | Neuropharmacological and Antidiarrheal Potentials of <i>Duabanga grandiflora</i> (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules |
| title_full | Neuropharmacological and Antidiarrheal Potentials of <i>Duabanga grandiflora</i> (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules |
| title_fullStr | Neuropharmacological and Antidiarrheal Potentials of <i>Duabanga grandiflora</i> (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules |
| title_full_unstemmed | Neuropharmacological and Antidiarrheal Potentials of <i>Duabanga grandiflora</i> (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules |
| title_short | Neuropharmacological and Antidiarrheal Potentials of <i>Duabanga grandiflora</i> (DC.) Walp. Stem Bark and Prospective Ligand–Receptor Interactions of Its Bioactive Lead Molecules |
| title_sort | neuropharmacological and antidiarrheal potentials of i duabanga grandiflora i dc walp stem bark and prospective ligand receptor interactions of its bioactive lead molecules |
| topic | <i>Duabanga grandiflora</i> (DC.) Walp. anti-depressant anxiolytic anti-diarrheal vanillin |
| url | https://www.mdpi.com/1467-3045/44/5/159 |
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