HUMORAL IMMUNITY RESPONSES AFTER VACCINATION FOR HEPATITIS B VIRUS IN AUTOGRAFTED PATIENTS: A SINGLE CENTER EXPERIENCE
Objective: The effectiveness of vaccinations post hematopoietic stem cell transplantation (HSCT), is a reliable marker for immune system's functionality assessment. In autologous HSCT (AHSCT) setting, the general aspect is that the immune system recovers quite soon and patients (pts) are consid...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137922013396 |
| _version_ | 1828107535457976320 |
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| author | Panayotis Kaloyannidis Naeema Al Musailemelime Abdulelah Al Shami Manal Al Enazi Norah Al Mulhem Ahmed Bahrani Rabab Attas Solaf Kanfar |
| author_facet | Panayotis Kaloyannidis Naeema Al Musailemelime Abdulelah Al Shami Manal Al Enazi Norah Al Mulhem Ahmed Bahrani Rabab Attas Solaf Kanfar |
| author_sort | Panayotis Kaloyannidis |
| collection | DOAJ |
| description | Objective: The effectiveness of vaccinations post hematopoietic stem cell transplantation (HSCT), is a reliable marker for immune system's functionality assessment. In autologous HSCT (AHSCT) setting, the general aspect is that the immune system recovers quite soon and patients (pts) are considered to be immunocompetent in a period of approximately 3-6 months post AHSCT. We evaluated the hepatitis B virus (HBV) vaccination responses in autografted pts who were in remission and off chemotherapy post AHSCT. Methodology: 27 autografted pts aged 51,6 (22-67) ys, who had antiHbs titers <10 IU/ml before AHSCT and at the time of vaccination, were studied. After a successful engraftment the median absolute lymphocytes count at +3 months was 1740(450-4090)/mm3. In 4,3(0,6–8,5) ys post AHSCT, 3 doses of recombinant HBV vaccine were given monthly. The response rates for pts who completed 3 vaccine doses, compared with an internal group of healthy individuals, vaccinated in the same period with the same product. Results: After the 1st, 2nd and 3rd dose the response rates in the study group were 11%, 81% and 88% respectively. No factor statistically significantly influenced the achievement of protective antiHbs titers. The responses were lower as compared to product's efficacy profile (19%, 86% and 100% after the 1st, 2nd and 3rd dose respectively), while in the comparative analysis with the internal control group, a trend for inferior responses in autografted pts was also noticed (88% vs 100%, p=0,07). Conclusion: This study, in a relatively homogenous group of pts, to our knowledge, is the only one that directly compares the HBV vaccine responses in autografted pts with healthy individuals. Although vaccination was offered late post AHSCT, the responses were lower compared to healthy individuals, indicating a possible long lasting immune impairment post AHSCT highlighting the necessity of prolonged surveillance and intensified vaccination programs for autografted pts. |
| first_indexed | 2024-04-11T10:32:36Z |
| format | Article |
| id | doaj.art-6dfb949224fa457da9f780ce94516eef |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-04-11T10:32:36Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-6dfb949224fa457da9f780ce94516eef2022-12-22T04:29:23ZengElsevierHematology, Transfusion and Cell Therapy2531-13792022-10-0144S17HUMORAL IMMUNITY RESPONSES AFTER VACCINATION FOR HEPATITIS B VIRUS IN AUTOGRAFTED PATIENTS: A SINGLE CENTER EXPERIENCEPanayotis Kaloyannidis0Naeema Al Musailemelime1Abdulelah Al Shami2Manal Al Enazi3Norah Al Mulhem4Ahmed Bahrani5Rabab Attas6Solaf Kanfar7Adult Hematology & Stem Cell Transplantation Department. King Fahad Specialist HospitalAdult Hematology & Stem Cell Transplantation Department. King Fahad Specialist HospitalAdult Hematology & Stem Cell Transplantation Department. King Fahad Specialist HospitalFamily Medicine Department. King Fahad Specialist HospitalDepartment of Pathology and Laboratory Medicine. King Fahad Specialist HospitalDepartment of Pathology and Laboratory Medicine. King Fahad Specialist HospitalDepartment of Pathology and Laboratory Medicine. King Fahad Specialist HospitalAdult Hematology & Stem Cell Transplantation Department. King Fahad Specialist HospitalObjective: The effectiveness of vaccinations post hematopoietic stem cell transplantation (HSCT), is a reliable marker for immune system's functionality assessment. In autologous HSCT (AHSCT) setting, the general aspect is that the immune system recovers quite soon and patients (pts) are considered to be immunocompetent in a period of approximately 3-6 months post AHSCT. We evaluated the hepatitis B virus (HBV) vaccination responses in autografted pts who were in remission and off chemotherapy post AHSCT. Methodology: 27 autografted pts aged 51,6 (22-67) ys, who had antiHbs titers <10 IU/ml before AHSCT and at the time of vaccination, were studied. After a successful engraftment the median absolute lymphocytes count at +3 months was 1740(450-4090)/mm3. In 4,3(0,6–8,5) ys post AHSCT, 3 doses of recombinant HBV vaccine were given monthly. The response rates for pts who completed 3 vaccine doses, compared with an internal group of healthy individuals, vaccinated in the same period with the same product. Results: After the 1st, 2nd and 3rd dose the response rates in the study group were 11%, 81% and 88% respectively. No factor statistically significantly influenced the achievement of protective antiHbs titers. The responses were lower as compared to product's efficacy profile (19%, 86% and 100% after the 1st, 2nd and 3rd dose respectively), while in the comparative analysis with the internal control group, a trend for inferior responses in autografted pts was also noticed (88% vs 100%, p=0,07). Conclusion: This study, in a relatively homogenous group of pts, to our knowledge, is the only one that directly compares the HBV vaccine responses in autografted pts with healthy individuals. Although vaccination was offered late post AHSCT, the responses were lower compared to healthy individuals, indicating a possible long lasting immune impairment post AHSCT highlighting the necessity of prolonged surveillance and intensified vaccination programs for autografted pts.http://www.sciencedirect.com/science/article/pii/S2531137922013396 |
| spellingShingle | Panayotis Kaloyannidis Naeema Al Musailemelime Abdulelah Al Shami Manal Al Enazi Norah Al Mulhem Ahmed Bahrani Rabab Attas Solaf Kanfar HUMORAL IMMUNITY RESPONSES AFTER VACCINATION FOR HEPATITIS B VIRUS IN AUTOGRAFTED PATIENTS: A SINGLE CENTER EXPERIENCE Hematology, Transfusion and Cell Therapy |
| title | HUMORAL IMMUNITY RESPONSES AFTER VACCINATION FOR HEPATITIS B VIRUS IN AUTOGRAFTED PATIENTS: A SINGLE CENTER EXPERIENCE |
| title_full | HUMORAL IMMUNITY RESPONSES AFTER VACCINATION FOR HEPATITIS B VIRUS IN AUTOGRAFTED PATIENTS: A SINGLE CENTER EXPERIENCE |
| title_fullStr | HUMORAL IMMUNITY RESPONSES AFTER VACCINATION FOR HEPATITIS B VIRUS IN AUTOGRAFTED PATIENTS: A SINGLE CENTER EXPERIENCE |
| title_full_unstemmed | HUMORAL IMMUNITY RESPONSES AFTER VACCINATION FOR HEPATITIS B VIRUS IN AUTOGRAFTED PATIENTS: A SINGLE CENTER EXPERIENCE |
| title_short | HUMORAL IMMUNITY RESPONSES AFTER VACCINATION FOR HEPATITIS B VIRUS IN AUTOGRAFTED PATIENTS: A SINGLE CENTER EXPERIENCE |
| title_sort | humoral immunity responses after vaccination for hepatitis b virus in autografted patients a single center experience |
| url | http://www.sciencedirect.com/science/article/pii/S2531137922013396 |
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