Cognitive Alterations in Addictive Disorders: A Translational Approach
The cognitive decline in people with substance use disorders is well known and can be found during both the dependence and drug abstinence phases. At the clinical level, cognitive decline impairs the response to addiction treatment and increases dropout rates. It can be irreversible, even after the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/7/1796 |
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| author | Ani Gasparyan Daniel Maldonado Sanchez Francisco Navarrete Ana Sion Daniela Navarro María Salud García-Gutiérrez Gabriel Rubio Valladolid Rosa Jurado Barba Jorge Manzanares |
| author_facet | Ani Gasparyan Daniel Maldonado Sanchez Francisco Navarrete Ana Sion Daniela Navarro María Salud García-Gutiérrez Gabriel Rubio Valladolid Rosa Jurado Barba Jorge Manzanares |
| author_sort | Ani Gasparyan |
| collection | DOAJ |
| description | The cognitive decline in people with substance use disorders is well known and can be found during both the dependence and drug abstinence phases. At the clinical level, cognitive decline impairs the response to addiction treatment and increases dropout rates. It can be irreversible, even after the end of drug abuse consumption. Improving our understanding of the molecular and cellular alterations associated with cognitive decline could be essential to developing specific therapeutic strategies for its treatment. Developing animal models to simulate drug abuse-induced learning and memory alterations is critical to continue exploring this clinical situation. The main aim of this review is to summarize the most recent evidence on cognitive impairment and the associated biological markers in patients addicted to some of the most consumed drugs of abuse and in animal models simulating this clinical situation. The available information suggests the need to develop more studies to further explore the molecular alterations associated with cognitive impairment, with the ultimate goal of developing new potential therapeutic strategies. |
| first_indexed | 2024-03-11T01:16:40Z |
| format | Article |
| id | doaj.art-6dfb9b1440e342f0972d73d466eb8dcf |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T01:16:40Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-6dfb9b1440e342f0972d73d466eb8dcf2023-11-18T18:25:05ZengMDPI AGBiomedicines2227-90592023-06-01117179610.3390/biomedicines11071796Cognitive Alterations in Addictive Disorders: A Translational ApproachAni Gasparyan0Daniel Maldonado Sanchez1Francisco Navarrete2Ana Sion3Daniela Navarro4María Salud García-Gutiérrez5Gabriel Rubio Valladolid6Rosa Jurado Barba7Jorge Manzanares8Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, 03550 San Juan de Alicante, SpainInstituto de Investigación i+12, Hospital Universitario 12 de Octubre, 28041 Madrid, SpainInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, 03550 San Juan de Alicante, SpainInstituto de Investigación i+12, Hospital Universitario 12 de Octubre, 28041 Madrid, SpainInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, 03550 San Juan de Alicante, SpainInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, 03550 San Juan de Alicante, SpainRedes de Investigación Cooperativa Orientada a Resultados en Salud (RICORS), Red de Investigación en Atención Primaria de Adicciones (RIAPAd), Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, SpainInstituto de Investigación i+12, Hospital Universitario 12 de Octubre, 28041 Madrid, SpainInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, 03550 San Juan de Alicante, SpainThe cognitive decline in people with substance use disorders is well known and can be found during both the dependence and drug abstinence phases. At the clinical level, cognitive decline impairs the response to addiction treatment and increases dropout rates. It can be irreversible, even after the end of drug abuse consumption. Improving our understanding of the molecular and cellular alterations associated with cognitive decline could be essential to developing specific therapeutic strategies for its treatment. Developing animal models to simulate drug abuse-induced learning and memory alterations is critical to continue exploring this clinical situation. The main aim of this review is to summarize the most recent evidence on cognitive impairment and the associated biological markers in patients addicted to some of the most consumed drugs of abuse and in animal models simulating this clinical situation. The available information suggests the need to develop more studies to further explore the molecular alterations associated with cognitive impairment, with the ultimate goal of developing new potential therapeutic strategies.https://www.mdpi.com/2227-9059/11/7/1796cognitionmemory and learningsubstance abusehuman studiesanimal modelsmolecular changes |
| spellingShingle | Ani Gasparyan Daniel Maldonado Sanchez Francisco Navarrete Ana Sion Daniela Navarro María Salud García-Gutiérrez Gabriel Rubio Valladolid Rosa Jurado Barba Jorge Manzanares Cognitive Alterations in Addictive Disorders: A Translational Approach Biomedicines cognition memory and learning substance abuse human studies animal models molecular changes |
| title | Cognitive Alterations in Addictive Disorders: A Translational Approach |
| title_full | Cognitive Alterations in Addictive Disorders: A Translational Approach |
| title_fullStr | Cognitive Alterations in Addictive Disorders: A Translational Approach |
| title_full_unstemmed | Cognitive Alterations in Addictive Disorders: A Translational Approach |
| title_short | Cognitive Alterations in Addictive Disorders: A Translational Approach |
| title_sort | cognitive alterations in addictive disorders a translational approach |
| topic | cognition memory and learning substance abuse human studies animal models molecular changes |
| url | https://www.mdpi.com/2227-9059/11/7/1796 |
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