Synthesis, molecular docking and DFT analysis of novel bis-Schiff base derivatives with thiobarbituric acid for α-glucosidase inhibition assessment

Synthesis, molecular docking and DFT analysis of novel bis-Schiff base derivatives with thiobarbituric acid for α-glucosidase inhibition assessment

Abstract A library of novel bis-Schiff base derivatives based on thiobarbituric acid has been effectively synthesized by multi-step reactions as part of our ongoing pursuit of novel anti-diabetic agents. All these derivatives were subjected to in vitro α-glucosidase inhibitory potential testing afte...

Full description

Bibliographic Details
Main Authors: Saba Gul, Faheem Jan, Aftab Alam, Abdul Shakoor, Ajmal Khan, Abdullah F. AlAsmari, Fawaz Alasmari, Momin Khan, Li Bo
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Thiobarbituric acid
bis-Schiff bases
α-Glucosidase inhibition
NMR spectroscopy
Molecular docking
DFT
Online Access:https://doi.org/10.1038/s41598-024-54021-z

Similar Items

Similar Items