Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion

Recent evidence suggests that autophagy facilitates the unconventional secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β). Here, we reconstituted an autophagy-regulated secretion of mature IL-1β (m-IL-1β) in non-macrophage cells. We found that cytoplasmic IL-1β associates with the aut...

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Bibliographic Details
Main Authors: Min Zhang, Samuel J Kenny, Liang Ge, Ke Xu, Randy Schekman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-11-01
Series:eLife
Subjects:
autophagy
unconventional secretion
interleukin-1β
HSP90
autophagosome
Online Access:https://elifesciences.org/articles/11205

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