Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes

Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes

C-X-C Motif Chemokine Ligand 10 (CXCL10) is a pro-inflammatory chemokine specifically recognized by the ligand receptor CXCR3 which is mostly expressed in T-lymphocytes. Although CXCL10 expression and secretion have been widely associated to pancreatic islets both in non-obese diabetic (NOD) mice an...

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Bibliographic Details
Main Authors: Laura Nigi, Noemi Brusco, Giuseppina E. Grieco, Giada Licata, Lars Krogvold, Lorella Marselli, Conny Gysemans, Lut Overbergh, Piero Marchetti, Chantal Mathieu, Knut Dahl Jørgensen, Guido Sebastiani, Francesco Dotta
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Endocrinology
Subjects:
type 1 diabetes
pancreas
alpha-cells
chemokines
CXCL10
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00630/full

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