Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy
Background: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN). Methods: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-05-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1288739 |
| _version_ | 1797681519037251584 |
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| author | Wenni Li Junlin Wang Lina Ge Jiehui Shan Chunbing Zhang Jianping Liu |
| author_facet | Wenni Li Junlin Wang Lina Ge Jiehui Shan Chunbing Zhang Jianping Liu |
| author_sort | Wenni Li |
| collection | DOAJ |
| description | Background: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN). Methods: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric diabetic patients, 122 with microalbuminuria, and 100 with macroalbuminuria, were recruited. Plasma Gas6 and serum cystatin C levels were measured. Results: Plasma Gas6 concentration was significantly lower in diabetic patients with microalbuminuria or macroalbuminuria, as compared with diabetic subjects with normoalbuminuria; while cystatin C was significantly higher. Gas6 was inversely correlated with BMI, WHR, and HbA1c, while cystatin C was inversely correlated with urea nitrogen and creatinine. Multivariate logistic regression analysis showed that, after adjusted for established diabetes risk factors, higher plasma Gas6 was significantly associated with a decreased risk of DN, while higher serum cystatin C was significantly associated with an increased risk. Receiver operating characteristic curve analysis showed that Gas6 was better than cystatin C as a biomarker for early diagnosis and detection of DN, with a cutoff value of 9.435 ng/mL (86.1% sensitivity and 84.6% specificity). Conclusion: Compared to cystatin C, Gas6 may be potentially a better noninvasive diagnostic biomarker for early detection of DN. |
| first_indexed | 2024-03-11T23:46:00Z |
| format | Article |
| id | doaj.art-6e026b3c0a334fe2bbaef03e55fe59e1 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:46:00Z |
| publishDate | 2017-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-6e026b3c0a334fe2bbaef03e55fe59e12023-09-19T09:24:45ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062017-05-0139438238710.1080/10641963.2017.12887391288739Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathyWenni Li0Junlin Wang1Lina Ge2Jiehui Shan3Chunbing Zhang4Jianping Liu5Shanghai Jiaotong UniversityShanghai Jiaotong UniversityShanghai Jiaotong UniversityShanghai Jiaotong UniversityShanghai Jiaotong UniversityShanghai Jiaotong UniversityBackground: To investigate the diagnostic level of cystatin C and growth arrest-specific gene 6 (Gas6) levels in elderly type 2 diabetic patients with different degrees of diabetic nephropathy (DN). Methods: Four hundred and eighty-two old people, including 130 healthy controls, 130 normoalbuminuric diabetic patients, 122 with microalbuminuria, and 100 with macroalbuminuria, were recruited. Plasma Gas6 and serum cystatin C levels were measured. Results: Plasma Gas6 concentration was significantly lower in diabetic patients with microalbuminuria or macroalbuminuria, as compared with diabetic subjects with normoalbuminuria; while cystatin C was significantly higher. Gas6 was inversely correlated with BMI, WHR, and HbA1c, while cystatin C was inversely correlated with urea nitrogen and creatinine. Multivariate logistic regression analysis showed that, after adjusted for established diabetes risk factors, higher plasma Gas6 was significantly associated with a decreased risk of DN, while higher serum cystatin C was significantly associated with an increased risk. Receiver operating characteristic curve analysis showed that Gas6 was better than cystatin C as a biomarker for early diagnosis and detection of DN, with a cutoff value of 9.435 ng/mL (86.1% sensitivity and 84.6% specificity). Conclusion: Compared to cystatin C, Gas6 may be potentially a better noninvasive diagnostic biomarker for early detection of DN.http://dx.doi.org/10.1080/10641963.2017.1288739biomarkercystatin cdiabetic nephropathy (dn)early detectiongrowth arrest-specific gene 6 (gas6) |
| spellingShingle | Wenni Li Junlin Wang Lina Ge Jiehui Shan Chunbing Zhang Jianping Liu Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy Clinical and Experimental Hypertension biomarker cystatin c diabetic nephropathy (dn) early detection growth arrest-specific gene 6 (gas6) |
| title | Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy |
| title_full | Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy |
| title_fullStr | Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy |
| title_full_unstemmed | Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy |
| title_short | Growth arrest-specific protein 6 (Gas6) as a noninvasive biomarker for early detection of diabetic nephropathy |
| title_sort | growth arrest specific protein 6 gas6 as a noninvasive biomarker for early detection of diabetic nephropathy |
| topic | biomarker cystatin c diabetic nephropathy (dn) early detection growth arrest-specific gene 6 (gas6) |
| url | http://dx.doi.org/10.1080/10641963.2017.1288739 |
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