Development of a sensitive and stable GC-MS/MS method for simultaneous determination of four N-nitrosamine genotoxic impurities in sartan substances

Development of a sensitive and stable GC-MS/MS method for simultaneous determination of four N-nitrosamine genotoxic impurities in sartan substances

Abstract Recently, N-nitrosamines have been unexpectedly found in generic sartan products. Herein, we developed a sensitive and stable GC-MS/MS method with multiple reactions monitoring mode for the simultaneous determination of four N-nitrosamines in sartan substances, namely, N-nitrosodimethylamin...

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Bibliographic Details
Main Authors: Jie Liu, Bin Xie, Binliang Mai, Qiang Cai, Rujian He, Dong Guo, Zhifeng Zhang, Jun Fan, Weiguang Zhang
Format: Article
Language:English
Published: SpringerOpen 2021-01-01
Series:Journal of Analytical Science and Technology
Subjects:
Sartan substances
N-nitrosamine genotoxic impurity
GC-MS/MS
Multiple reactions monitoring
Quantitative determination
Online Access:https://doi.org/10.1186/s40543-020-00254-2

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