Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical Significance
Purpose: To assess the potential added value of the SPECT-CT quantitative analysis in metastatic breast cancer lesions detection and differentiation from degenerative lesions. Methods: This prospective monocentric study was conducted on 70 female patients who underwent SPECT-CT bone scans using <...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/2/273 |
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| author | Mirela Gherghe Mario-Demian Mutuleanu Adina Elena Stanciu Ionela Irimescu Alexandra Lazar Xenia Bacinschi Rodica Maricela Anghel |
| author_facet | Mirela Gherghe Mario-Demian Mutuleanu Adina Elena Stanciu Ionela Irimescu Alexandra Lazar Xenia Bacinschi Rodica Maricela Anghel |
| author_sort | Mirela Gherghe |
| collection | DOAJ |
| description | Purpose: To assess the potential added value of the SPECT-CT quantitative analysis in metastatic breast cancer lesions detection and differentiation from degenerative lesions. Methods: This prospective monocentric study was conducted on 70 female patients who underwent SPECT-CT bone scans using <sup>99m</sup>Tc–HDP that identified the presence of metastatic bone lesions and degenerative lesions in each patient. Once the lesions were identified, a quantitative analysis of radiotracer uptake was conducted. The highest one to five SUVmax values for both metastatic and degenerative bone lesions were identified in each patient and the data were then statistically analyzed. Results: The SUVmax value was significantly higher in metastatic bone lesions than in degenerative lesions (<i>p</i> < 0.001). The diagnostic accuracy of SPECT-CT quantitative data analysis revealed a sensitivity of 91.5% and a specificity of 93.3% at a cut-off value of the SUVmax of 16.6 g/mL. Conclusion: Quantitative analysis performed using SPECT-CT data can improve the diagnostic accuracy in differentiating between metastatic bone lesions and degenerative lesions, thus leading to appropriate treatment and better follow-up in metastatic breast cancer patients. |
| first_indexed | 2024-03-10T01:47:10Z |
| format | Article |
| id | doaj.art-6e0331e7c67241bfafdcc96ebc56f321 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T01:47:10Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-6e0331e7c67241bfafdcc96ebc56f3212023-11-23T13:12:13ZengMDPI AGCancers2072-66942022-01-0114227310.3390/cancers14020273Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical SignificanceMirela Gherghe0Mario-Demian Mutuleanu1Adina Elena Stanciu2Ionela Irimescu3Alexandra Lazar4Xenia Bacinschi5Rodica Maricela Anghel6Nuclear Medicine Department, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, RomaniaNuclear Medicine Department, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, RomaniaCarcinogenesis and Molecular Biology Department, Institute of Oncology “Prof.Dr. Alexandru Trestioreanu”, 022328 Bucharest, RomaniaNuclear Medicine Department, Institute of Oncology “Prof.Dr. Alexandru Trestioreanu”, 022328 Bucharest, RomaniaNuclear Medicine Department, Institute of Oncology “Prof.Dr. Alexandru Trestioreanu”, 022328 Bucharest, RomaniaOncology Department, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, RomaniaOncology Department, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, RomaniaPurpose: To assess the potential added value of the SPECT-CT quantitative analysis in metastatic breast cancer lesions detection and differentiation from degenerative lesions. Methods: This prospective monocentric study was conducted on 70 female patients who underwent SPECT-CT bone scans using <sup>99m</sup>Tc–HDP that identified the presence of metastatic bone lesions and degenerative lesions in each patient. Once the lesions were identified, a quantitative analysis of radiotracer uptake was conducted. The highest one to five SUVmax values for both metastatic and degenerative bone lesions were identified in each patient and the data were then statistically analyzed. Results: The SUVmax value was significantly higher in metastatic bone lesions than in degenerative lesions (<i>p</i> < 0.001). The diagnostic accuracy of SPECT-CT quantitative data analysis revealed a sensitivity of 91.5% and a specificity of 93.3% at a cut-off value of the SUVmax of 16.6 g/mL. Conclusion: Quantitative analysis performed using SPECT-CT data can improve the diagnostic accuracy in differentiating between metastatic bone lesions and degenerative lesions, thus leading to appropriate treatment and better follow-up in metastatic breast cancer patients.https://www.mdpi.com/2072-6694/14/2/273quantitative analysisSPECT-CTSUVmaxbone metastatic lesionsbone degenerative lesions |
| spellingShingle | Mirela Gherghe Mario-Demian Mutuleanu Adina Elena Stanciu Ionela Irimescu Alexandra Lazar Xenia Bacinschi Rodica Maricela Anghel Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical Significance Cancers quantitative analysis SPECT-CT SUVmax bone metastatic lesions bone degenerative lesions |
| title | Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical Significance |
| title_full | Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical Significance |
| title_fullStr | Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical Significance |
| title_full_unstemmed | Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical Significance |
| title_short | Quantitative Analysis of SPECT-CT Data in Metastatic Breast Cancer Patients—The Clinical Significance |
| title_sort | quantitative analysis of spect ct data in metastatic breast cancer patients the clinical significance |
| topic | quantitative analysis SPECT-CT SUVmax bone metastatic lesions bone degenerative lesions |
| url | https://www.mdpi.com/2072-6694/14/2/273 |
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