Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency
The aim of this study was to determine the blood levels of pro- and anti-inflammatory cytokines in patients with moderate and severe pelvic venous insufficiency (PVI). Methods and Results: One hundred and four women with PVI and 30 healthy women (control group [CG]) of reproductive age were examine...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2023-03-01
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| Series: | International Journal of Biomedicine |
| Subjects: | |
| Online Access: | http://www.ijbm.org/articles/i49/ijbm_13(1)_oa5.pdf |
| _version_ | 1811160034794536960 |
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| author | Marina A. Darenskaya Andrey A. Semendyaev Dmitriy A. Stupin Sergey I. Kolesnikov Natalya V. Semenova Konstantin V. Pesterev Lyubov I. Kolesnikova |
| author_facet | Marina A. Darenskaya Andrey A. Semendyaev Dmitriy A. Stupin Sergey I. Kolesnikov Natalya V. Semenova Konstantin V. Pesterev Lyubov I. Kolesnikova |
| author_sort | Marina A. Darenskaya |
| collection | DOAJ |
| description | The aim of this study was to determine the blood levels of pro- and anti-inflammatory cytokines in patients with moderate and severe pelvic venous insufficiency (PVI).
Methods and Results: One hundred and four women with PVI and 30 healthy women (control group [CG]) of reproductive age were examined. The patients with PVI (main group [MG]) were divided into 2 subgroups according to the severity of the disease: MG-moderate (n=63) and MG-severe (n=41). The concentration of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-8), and anti-inflammatory interleukins IL-4 and IL-10 were assessed by enzyme immunoassay using monoclonal antibody panels. Measurements were performed on a microplate photometer. Data analysis showed higher values of pro-inflammatory factors (IL-1β, IL-6, and IL-8) in the MG-moderate than in the CG. The MG-severe, compared with the CG, had high levels of IL-1β, IL-2, IL-6, IL-8, and low IL-10 concentration. In addition, patients of the MG-severe had higher levels of IL-2 than patients of the MG-moderate (P=0.045). The IL-6/IL-10 ratio was characterized by higher values in the MG-moderate and MG-severe than in the CG (P<0.0001). The patients of the MG-severe also had higher levels of the IL-6/IL-10 ratio than patients of the MG-moderate (P=0.020).
Conclusion: In patients with PVI with increasing severity of varicose veins, the pro- and anti-inflammatory cytokine balance is progressively disturbed toward the dominance of pro-inflammatory components. The control of these changes in patients is an important component of the design of therapeutic measures and prevention of morphofunctional disorders occurring with the progression of the disease.
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| first_indexed | 2024-04-10T05:50:46Z |
| format | Article |
| id | doaj.art-6e0613f959074b47987c187cbc409b24 |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-04-10T05:50:46Z |
| publishDate | 2023-03-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-6e0613f959074b47987c187cbc409b242023-03-05T00:21:56ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292023-03-01131545710.21103/Article13(1)_OA5Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous InsufficiencyMarina A. Darenskaya0Andrey A. Semendyaev1Dmitriy A. Stupin2Sergey I. Kolesnikov3Natalya V. Semenova4Konstantin V. Pesterev5Lyubov I. Kolesnikova6Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationIrkutsk State Medical University, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian Federation; Irkutsk State Medical University, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationIrkutsk State Medical University, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationThe aim of this study was to determine the blood levels of pro- and anti-inflammatory cytokines in patients with moderate and severe pelvic venous insufficiency (PVI). Methods and Results: One hundred and four women with PVI and 30 healthy women (control group [CG]) of reproductive age were examined. The patients with PVI (main group [MG]) were divided into 2 subgroups according to the severity of the disease: MG-moderate (n=63) and MG-severe (n=41). The concentration of pro-inflammatory cytokines (IL-1β, IL-2, IL-6, IL-8), and anti-inflammatory interleukins IL-4 and IL-10 were assessed by enzyme immunoassay using monoclonal antibody panels. Measurements were performed on a microplate photometer. Data analysis showed higher values of pro-inflammatory factors (IL-1β, IL-6, and IL-8) in the MG-moderate than in the CG. The MG-severe, compared with the CG, had high levels of IL-1β, IL-2, IL-6, IL-8, and low IL-10 concentration. In addition, patients of the MG-severe had higher levels of IL-2 than patients of the MG-moderate (P=0.045). The IL-6/IL-10 ratio was characterized by higher values in the MG-moderate and MG-severe than in the CG (P<0.0001). The patients of the MG-severe also had higher levels of the IL-6/IL-10 ratio than patients of the MG-moderate (P=0.020). Conclusion: In patients with PVI with increasing severity of varicose veins, the pro- and anti-inflammatory cytokine balance is progressively disturbed toward the dominance of pro-inflammatory components. The control of these changes in patients is an important component of the design of therapeutic measures and prevention of morphofunctional disorders occurring with the progression of the disease. http://www.ijbm.org/articles/i49/ijbm_13(1)_oa5.pdfpelvic venous insufficiencywomencytokines |
| spellingShingle | Marina A. Darenskaya Andrey A. Semendyaev Dmitriy A. Stupin Sergey I. Kolesnikov Natalya V. Semenova Konstantin V. Pesterev Lyubov I. Kolesnikova Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency International Journal of Biomedicine pelvic venous insufficiency women cytokines |
| title | Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency |
| title_full | Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency |
| title_fullStr | Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency |
| title_full_unstemmed | Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency |
| title_short | Pro- and Anti-Inflammatory Blood Cytokines Levels in Women with Moderate and Severe Pelvic Venous Insufficiency |
| title_sort | pro and anti inflammatory blood cytokines levels in women with moderate and severe pelvic venous insufficiency |
| topic | pelvic venous insufficiency women cytokines |
| url | http://www.ijbm.org/articles/i49/ijbm_13(1)_oa5.pdf |
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