FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis

FGF19/FGFR4 signaling axis confines and switches the role of melatonin in head and neck cancer metastasis

Abstract Background There is no consensus about the effective dosages of melatonin in cancer management, thus, it is imperative to fully understand the dose-dependent responsiveness of cancer cells to melatonin and the underlying mechanisms. Methods Head and neck squamous cell carcinoma (HNSCC) cell...

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Bibliographic Details
Main Authors: Liwei Lang, Yuanping Xiong, Nestor Prieto-Dominguez, Reid Loveless, Caleb Jensen, Chloe Shay, Yong Teng
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
FGF19/FGFR4 axis
Melatonin
ER stress
Metastases
H3B-6527
HNSCC
Online Access:https://doi.org/10.1186/s13046-021-01888-9

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