CLINICAL MORPHOLOGY OF THE LIVER: NECROSES
Background. An objective morphological conclusion about the presence of lesions in the liver can be given only by a qualified clinical morphologist, who operates using the existing international criteria for evaluation of the most typical changes in the liver, including characteristics of necros...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Belarusian |
| Published: |
Grodno State Medical University
2017-12-01
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| Series: | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| Subjects: | |
| Online Access: | http://journal-grsmu.by/index.php/ojs/article/view/2201/2020 |
| _version_ | 1818756019781632000 |
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| author | Tsyrkunov V. M. Prokopchik N. I. Andreev V. P. Kravchuk R. I. |
| author_facet | Tsyrkunov V. M. Prokopchik N. I. Andreev V. P. Kravchuk R. I. |
| author_sort | Tsyrkunov V. M. |
| collection | DOAJ |
| description | Background. An objective morphological conclusion about the presence of lesions in the liver can be given only
by a qualified clinical morphologist, who operates using the existing international criteria for evaluation of the most
typical changes in the liver, including characteristics of necrosis.
The aim is to present the morphological characteristics of liver necroses according to the data of intravital liver
biopsy in chronic diffuse lesions of various etiologies.
Material and methods. Liver biopsy was obtained by performing aspiration liver biopsy in patients with chronic
viral, alcoholic, toxic and metabolic liver lesions, whose written informed consent had been obtained.
We used the methods of light microscopy including semifine sections and those of electron microscopy.
Results. The photomicrographs represent the most typical samples (types) of necroses – coagulation and
colliquative, descriptions and images of the changes in the hepatocyte cell nucleus (karyopyknosis, karyorrhexis,
karyolysis) and cytoplasm (coagulation and lysis of cytoplasmic proteins, their breakdown with detritus formation
and cytolysis). Necroses characteristics corresponding to the international morphological classification are presented
in detail. Depending on the area of necroses proliferation, their localization in the liver lobule and severity the
following variants of hepatocyte necrosis are distinguished: monocellular; focal (spotted); stepped; zonal; acinar;
bridged (port-portal, port-central, centro-central); submassive; massive. The main criteria for the semi-quantitative
evaluation of necrosis used in clinical practice in different countries are presented.
Conclusions. In vivo morphological diagnostics makes it possible to determine the stage of development, the nature
(type) and preferential localization of necrosis, to assume its etiology, to predict the course and outcome of liver
damage. An essential factor that increases the quality of diagnosis is the simultaneous morphological study of a single
biopsy by light and electron microscopy. |
| first_indexed | 2024-12-18T05:48:23Z |
| format | Article |
| id | doaj.art-6e071ae713f1416db3ba12a1f0596de1 |
| institution | Directory Open Access Journal |
| issn | 2221-8785 2413-0109 |
| language | Belarusian |
| last_indexed | 2024-12-18T05:48:23Z |
| publishDate | 2017-12-01 |
| publisher | Grodno State Medical University |
| record_format | Article |
| series | Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta |
| spelling | doaj.art-6e071ae713f1416db3ba12a1f0596de12022-12-21T21:18:58ZbelGrodno State Medical UniversityŽurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta2221-87852413-01092017-12-0115555756810.25298/2221-8785-2017-15-5-557-568CLINICAL MORPHOLOGY OF THE LIVER: NECROSESTsyrkunov V. M.0Prokopchik N. I.1Andreev V. P.2Kravchuk R. I.3Education Institution «Grodno State Medical University»Educational Institution “Grodno State Medical UniversityEducational Institution «Grodno State Medical University»Educational Institution “Grodno State Medical University”Background. An objective morphological conclusion about the presence of lesions in the liver can be given only by a qualified clinical morphologist, who operates using the existing international criteria for evaluation of the most typical changes in the liver, including characteristics of necrosis. The aim is to present the morphological characteristics of liver necroses according to the data of intravital liver biopsy in chronic diffuse lesions of various etiologies. Material and methods. Liver biopsy was obtained by performing aspiration liver biopsy in patients with chronic viral, alcoholic, toxic and metabolic liver lesions, whose written informed consent had been obtained. We used the methods of light microscopy including semifine sections and those of electron microscopy. Results. The photomicrographs represent the most typical samples (types) of necroses – coagulation and colliquative, descriptions and images of the changes in the hepatocyte cell nucleus (karyopyknosis, karyorrhexis, karyolysis) and cytoplasm (coagulation and lysis of cytoplasmic proteins, their breakdown with detritus formation and cytolysis). Necroses characteristics corresponding to the international morphological classification are presented in detail. Depending on the area of necroses proliferation, their localization in the liver lobule and severity the following variants of hepatocyte necrosis are distinguished: monocellular; focal (spotted); stepped; zonal; acinar; bridged (port-portal, port-central, centro-central); submassive; massive. The main criteria for the semi-quantitative evaluation of necrosis used in clinical practice in different countries are presented. Conclusions. In vivo morphological diagnostics makes it possible to determine the stage of development, the nature (type) and preferential localization of necrosis, to assume its etiology, to predict the course and outcome of liver damage. An essential factor that increases the quality of diagnosis is the simultaneous morphological study of a single biopsy by light and electron microscopy.http://journal-grsmu.by/index.php/ojs/article/view/2201/2020livermorphologynecrosesvisualization |
| spellingShingle | Tsyrkunov V. M. Prokopchik N. I. Andreev V. P. Kravchuk R. I. CLINICAL MORPHOLOGY OF THE LIVER: NECROSES Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta liver morphology necroses visualization |
| title | CLINICAL MORPHOLOGY OF THE LIVER: NECROSES |
| title_full | CLINICAL MORPHOLOGY OF THE LIVER: NECROSES |
| title_fullStr | CLINICAL MORPHOLOGY OF THE LIVER: NECROSES |
| title_full_unstemmed | CLINICAL MORPHOLOGY OF THE LIVER: NECROSES |
| title_short | CLINICAL MORPHOLOGY OF THE LIVER: NECROSES |
| title_sort | clinical morphology of the liver necroses |
| topic | liver morphology necroses visualization |
| url | http://journal-grsmu.by/index.php/ojs/article/view/2201/2020 |
| work_keys_str_mv | AT tsyrkunovvm clinicalmorphologyofthelivernecroses AT prokopchikni clinicalmorphologyofthelivernecroses AT andreevvp clinicalmorphologyofthelivernecroses AT kravchukri clinicalmorphologyofthelivernecroses |