BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis
Abstract Background Breast cancer susceptibility gene (BRCA) mutation carriers are at an increased risk for breast, ovarian, prostate and pancreatic cancers. However, the role of BRCA is unclear in colorectal cancer; the results regarding the association between BRCA gene mutations and colorectal ca...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12885-023-11328-w |
| _version_ | 1827633972287373312 |
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| author | Zhewen Feng Xiaobao Yang Mingwei Tian Na Zeng Zhigang Bai Wei Deng Yanyan Zhao Jianru Guo Yingchi Yang Zhongtao Zhang Yun Yang |
| author_facet | Zhewen Feng Xiaobao Yang Mingwei Tian Na Zeng Zhigang Bai Wei Deng Yanyan Zhao Jianru Guo Yingchi Yang Zhongtao Zhang Yun Yang |
| author_sort | Zhewen Feng |
| collection | DOAJ |
| description | Abstract Background Breast cancer susceptibility gene (BRCA) mutation carriers are at an increased risk for breast, ovarian, prostate and pancreatic cancers. However, the role of BRCA is unclear in colorectal cancer; the results regarding the association between BRCA gene mutations and colorectal cancer risk are inconsistent and even controversial. This study aimed to investigate whether BRCA1 and BRCA2 gene mutations are associated with colorectal cancer risk. Methods In this systematic review, we searched PubMed/MEDLINE, Embase and Cochrane Library databases, adhering to PRISMA guidelines. Study quality was assessed using the Newcastle–Ottawa Scale (NOS). Unadjusted odds ratios (ORs) were used to estimate the probability of Breast Cancer Type 1 Susceptibility gene (BRCA1) and Breast Cancer Type 2 Susceptibility gene (BRCA2) mutations in colorectal cancer patients. The associations were evaluated using fixed effect models. Results Fourteen studies were included in the systematic review. Twelve studies, including seven case–control and five cohort studies, were included in the meta-analysis. A significant increase in the frequency of BRCA1 and BRCA2 mutations was observed in patients with colorectal cancer [OR = 1.34, 95% confidence interval (CI) = 1.02–1.76, P = 0.04]. In subgroup analysis, colorectal cancer patients had an increased odds of BRCA1 (OR = 1.48, 95% CI = 1.10–2.01, P = 0.01) and BRCA2 (OR = 1.56, 95% CI = 1.06–2.30, P = 0.02) mutations. Conclusions BRCA genes are one of the genes that may increase the risk of developing colorectal cancer. Thus, BRCA genes could be potential candidates that may be included in the colorectal cancer genetic testing panel. |
| first_indexed | 2024-03-09T15:06:47Z |
| format | Article |
| id | doaj.art-6e07dc219c7a4cae8384cfa166c02d58 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-09T15:06:47Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-6e07dc219c7a4cae8384cfa166c02d582023-11-26T13:35:42ZengBMCBMC Cancer1471-24072023-08-0123111010.1186/s12885-023-11328-wBRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysisZhewen Feng0Xiaobao Yang1Mingwei Tian2Na Zeng3Zhigang Bai4Wei Deng5Yanyan Zhao6Jianru Guo7Yingchi Yang8Zhongtao Zhang9Yun Yang10Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive DiseasesSchool of Public Health, Peking UniversityDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive DiseasesMyGene Diagnostics Co., LtdMyGene Diagnostics Co., LtdDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive DiseasesDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive DiseasesAbstract Background Breast cancer susceptibility gene (BRCA) mutation carriers are at an increased risk for breast, ovarian, prostate and pancreatic cancers. However, the role of BRCA is unclear in colorectal cancer; the results regarding the association between BRCA gene mutations and colorectal cancer risk are inconsistent and even controversial. This study aimed to investigate whether BRCA1 and BRCA2 gene mutations are associated with colorectal cancer risk. Methods In this systematic review, we searched PubMed/MEDLINE, Embase and Cochrane Library databases, adhering to PRISMA guidelines. Study quality was assessed using the Newcastle–Ottawa Scale (NOS). Unadjusted odds ratios (ORs) were used to estimate the probability of Breast Cancer Type 1 Susceptibility gene (BRCA1) and Breast Cancer Type 2 Susceptibility gene (BRCA2) mutations in colorectal cancer patients. The associations were evaluated using fixed effect models. Results Fourteen studies were included in the systematic review. Twelve studies, including seven case–control and five cohort studies, were included in the meta-analysis. A significant increase in the frequency of BRCA1 and BRCA2 mutations was observed in patients with colorectal cancer [OR = 1.34, 95% confidence interval (CI) = 1.02–1.76, P = 0.04]. In subgroup analysis, colorectal cancer patients had an increased odds of BRCA1 (OR = 1.48, 95% CI = 1.10–2.01, P = 0.01) and BRCA2 (OR = 1.56, 95% CI = 1.06–2.30, P = 0.02) mutations. Conclusions BRCA genes are one of the genes that may increase the risk of developing colorectal cancer. Thus, BRCA genes could be potential candidates that may be included in the colorectal cancer genetic testing panel.https://doi.org/10.1186/s12885-023-11328-wColorectal cancerBRCABRCA1BRCA2MutationGenetic testing |
| spellingShingle | Zhewen Feng Xiaobao Yang Mingwei Tian Na Zeng Zhigang Bai Wei Deng Yanyan Zhao Jianru Guo Yingchi Yang Zhongtao Zhang Yun Yang BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis BMC Cancer Colorectal cancer BRCA BRCA1 BRCA2 Mutation Genetic testing |
| title | BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis |
| title_full | BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis |
| title_fullStr | BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis |
| title_full_unstemmed | BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis |
| title_short | BRCA genes as candidates for colorectal cancer genetic testing panel: systematic review and meta-analysis |
| title_sort | brca genes as candidates for colorectal cancer genetic testing panel systematic review and meta analysis |
| topic | Colorectal cancer BRCA BRCA1 BRCA2 Mutation Genetic testing |
| url | https://doi.org/10.1186/s12885-023-11328-w |
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