Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinoma
Objective To detect factors associated with recurrence after nephron-sparing surgery (NSS) in patients with localized clear cell renal cell carcinoma (ccRCC), and to construct a model for predicting the recurrence risk in five years following NSS. Methods Data of the patients who underwent NSS for...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2021-03-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201251.pdf |
| _version_ | 1797365788598861824 |
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| author | CHEN Zhi-gang, HONG Peng, YANG Bin, TIAN Xiao-jun, WANG Guo-liang, ZHANG Shu-dong, MA Lu-lin |
| author_facet | CHEN Zhi-gang, HONG Peng, YANG Bin, TIAN Xiao-jun, WANG Guo-liang, ZHANG Shu-dong, MA Lu-lin |
| author_sort | CHEN Zhi-gang, HONG Peng, YANG Bin, TIAN Xiao-jun, WANG Guo-liang, ZHANG Shu-dong, MA Lu-lin |
| collection | DOAJ |
| description | Objective To detect factors associated with recurrence after nephron-sparing surgery (NSS) in patients with localized clear cell renal cell carcinoma (ccRCC), and to construct a model for predicting the recurrence risk in five years following NSS. Methods Data of the patients who underwent NSS for renal occupied lesions between January 2006 and July 2019 at Peking University Third Hospital were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to assess the factors associated with recurrence of ccRCC after NSS, and a nomogram was established to predict recurrence risk in 5 years following NSS. Results Totally 795 patients who were pathologically diagnosed with ccRCC were included in the study. Recurrence occurred in 17 cases, with the recurrence rate 2.1%. The median time to relapse was 35.7 months. In the univariable analysis, BMI (HR=4.102, P＜ 0.05), the artery blocking time (HR=0.194, P＜ 0.01) and tumor necrosis or sarcomatoid change (HR=5.160, P＜ 0.01) were associated with recurrence-free survival of the ccRCC patients after NSS. The multivariate analysis showed that these three factors were independent factors of recurrence. The accuracy of our nomogram for recurrence risk was verified using internal validation, and the value of c-index was 0.843. Conclusions BMI, artery blocking time and tumor necrosis or sarcomatoid change were independent factors for recurrence following NSS in the ccRCC patients. An accurate model to predict the recurrence risk is constructed, which may help to provide personalized managements for the aforementioned patients after NSS. |
| first_indexed | 2024-03-08T16:54:56Z |
| format | Article |
| id | doaj.art-6e0a5ff44c5d4ffb979a423a212b03ce |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:54:56Z |
| publishDate | 2021-03-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-6e0a5ff44c5d4ffb979a423a212b03ce2024-01-05T03:04:40ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252021-03-01413409414Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinomaCHEN Zhi-gang, HONG Peng, YANG Bin, TIAN Xiao-jun, WANG Guo-liang, ZHANG Shu-dong, MA Lu-lin01. Peking University Health Science Center, Beijing 100191; ;2. Department of Urology, Peking University Third Hospital, Beijing 100191, ChinaObjective To detect factors associated with recurrence after nephron-sparing surgery (NSS) in patients with localized clear cell renal cell carcinoma (ccRCC), and to construct a model for predicting the recurrence risk in five years following NSS. Methods Data of the patients who underwent NSS for renal occupied lesions between January 2006 and July 2019 at Peking University Third Hospital were retrospectively analyzed. Univariate and multivariate logistic regression analyses were used to assess the factors associated with recurrence of ccRCC after NSS, and a nomogram was established to predict recurrence risk in 5 years following NSS. Results Totally 795 patients who were pathologically diagnosed with ccRCC were included in the study. Recurrence occurred in 17 cases, with the recurrence rate 2.1%. The median time to relapse was 35.7 months. In the univariable analysis, BMI (HR=4.102, P＜ 0.05), the artery blocking time (HR=0.194, P＜ 0.01) and tumor necrosis or sarcomatoid change (HR=5.160, P＜ 0.01) were associated with recurrence-free survival of the ccRCC patients after NSS. The multivariate analysis showed that these three factors were independent factors of recurrence. The accuracy of our nomogram for recurrence risk was verified using internal validation, and the value of c-index was 0.843. Conclusions BMI, artery blocking time and tumor necrosis or sarcomatoid change were independent factors for recurrence following NSS in the ccRCC patients. An accurate model to predict the recurrence risk is constructed, which may help to provide personalized managements for the aforementioned patients after NSS.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201251.pdfclear cell renal cell carcinoma|nephron-sparing surgery|recurrence|prognosis|nomogram |
| spellingShingle | CHEN Zhi-gang, HONG Peng, YANG Bin, TIAN Xiao-jun, WANG Guo-liang, ZHANG Shu-dong, MA Lu-lin Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinoma Jichu yixue yu linchuang clear cell renal cell carcinoma|nephron-sparing surgery|recurrence|prognosis|nomogram |
| title | Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinoma |
| title_full | Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinoma |
| title_fullStr | Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinoma |
| title_full_unstemmed | Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinoma |
| title_short | Constructing a risk predictive model for recurrence following nephron-sparing surgery in the treatment of clear cell renal cell carcinoma |
| title_sort | constructing a risk predictive model for recurrence following nephron sparing surgery in the treatment of clear cell renal cell carcinoma |
| topic | clear cell renal cell carcinoma|nephron-sparing surgery|recurrence|prognosis|nomogram |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a201251.pdf |
| work_keys_str_mv | AT chenzhiganghongpengyangbintianxiaojunwangguoliangzhangshudongmalulin constructingariskpredictivemodelforrecurrencefollowingnephronsparingsurgeryinthetreatmentofclearcellrenalcellcarcinoma |