Disentangling Mitochondria in Alzheimer’s Disease
Alzheimer’s disease (AD) is a major cause of dementia in older adults and is fast becoming a major societal and economic burden due to an increase in life expectancy. Age seems to be the major factor driving AD, and currently, only symptomatic treatments are available. AD has a complex etiology, alt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/21/11520 |
| _version_ | 1797512498896699392 |
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| author | Ashu Johri |
| author_facet | Ashu Johri |
| author_sort | Ashu Johri |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a major cause of dementia in older adults and is fast becoming a major societal and economic burden due to an increase in life expectancy. Age seems to be the major factor driving AD, and currently, only symptomatic treatments are available. AD has a complex etiology, although mitochondrial dysfunction, oxidative stress, inflammation, and metabolic abnormalities have been widely and deeply investigated as plausible mechanisms for its neuropathology. Aβ plaques and hyperphosphorylated tau aggregates, along with cognitive deficits and behavioral problems, are the hallmarks of the disease. Restoration of mitochondrial bioenergetics, prevention of oxidative stress, and diet and exercise seem to be effective in reducing Aβ and in ameliorating learning and memory problems. Many mitochondria-targeted antioxidants have been tested in AD and are currently in development. However, larger streamlined clinical studies are needed to provide hard evidence of benefits in AD. This review discusses the causative factors, as well as potential therapeutics employed in the treatment of AD. |
| first_indexed | 2024-03-10T06:01:40Z |
| format | Article |
| id | doaj.art-6e0b2c5337454f8d8e279b517fa090ce |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:01:40Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-6e0b2c5337454f8d8e279b517fa090ce2023-11-22T20:53:31ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122211152010.3390/ijms222111520Disentangling Mitochondria in Alzheimer’s DiseaseAshu Johri0Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY 10065, USAAlzheimer’s disease (AD) is a major cause of dementia in older adults and is fast becoming a major societal and economic burden due to an increase in life expectancy. Age seems to be the major factor driving AD, and currently, only symptomatic treatments are available. AD has a complex etiology, although mitochondrial dysfunction, oxidative stress, inflammation, and metabolic abnormalities have been widely and deeply investigated as plausible mechanisms for its neuropathology. Aβ plaques and hyperphosphorylated tau aggregates, along with cognitive deficits and behavioral problems, are the hallmarks of the disease. Restoration of mitochondrial bioenergetics, prevention of oxidative stress, and diet and exercise seem to be effective in reducing Aβ and in ameliorating learning and memory problems. Many mitochondria-targeted antioxidants have been tested in AD and are currently in development. However, larger streamlined clinical studies are needed to provide hard evidence of benefits in AD. This review discusses the causative factors, as well as potential therapeutics employed in the treatment of AD.https://www.mdpi.com/1422-0067/22/21/11520Alzheimer’s diseaseneurodegenerationmitochondriaantioxidantsPGC-1αsirtuins |
| spellingShingle | Ashu Johri Disentangling Mitochondria in Alzheimer’s Disease International Journal of Molecular Sciences Alzheimer’s disease neurodegeneration mitochondria antioxidants PGC-1α sirtuins |
| title | Disentangling Mitochondria in Alzheimer’s Disease |
| title_full | Disentangling Mitochondria in Alzheimer’s Disease |
| title_fullStr | Disentangling Mitochondria in Alzheimer’s Disease |
| title_full_unstemmed | Disentangling Mitochondria in Alzheimer’s Disease |
| title_short | Disentangling Mitochondria in Alzheimer’s Disease |
| title_sort | disentangling mitochondria in alzheimer s disease |
| topic | Alzheimer’s disease neurodegeneration mitochondria antioxidants PGC-1α sirtuins |
| url | https://www.mdpi.com/1422-0067/22/21/11520 |
| work_keys_str_mv | AT ashujohri disentanglingmitochondriainalzheimersdisease |