mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1
Identification of low abundance proteins interacting with viral proteins can be challenging. Here, Du et al. develop an mRNA display approach with a library of even distribution, identify host proteins interacting with NS1 protein of influenza A virus, and show that one interactor provides a means t...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16140-9 |
| _version_ | 1819126266515685376 |
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| author | Yushen Du Judd F. Hultquist Quan Zhou Anders Olson Yenwen Tseng Tian-hao Zhang Mengying Hong Kejun Tang Liubo Chen Xiangzhi Meng Michael J. McGregor Lei Dai Danyang Gong Laura Martin-Sancho Sumit Chanda Xinming Li Steve Bensenger Nevan J. Krogan Ren Sun |
| author_facet | Yushen Du Judd F. Hultquist Quan Zhou Anders Olson Yenwen Tseng Tian-hao Zhang Mengying Hong Kejun Tang Liubo Chen Xiangzhi Meng Michael J. McGregor Lei Dai Danyang Gong Laura Martin-Sancho Sumit Chanda Xinming Li Steve Bensenger Nevan J. Krogan Ren Sun |
| author_sort | Yushen Du |
| collection | DOAJ |
| description | Identification of low abundance proteins interacting with viral proteins can be challenging. Here, Du et al. develop an mRNA display approach with a library of even distribution, identify host proteins interacting with NS1 protein of influenza A virus, and show that one interactor provides a means to regulate cellular fatty acids synthesis. |
| first_indexed | 2024-12-22T07:53:18Z |
| format | Article |
| id | doaj.art-6e0ba4fb71cb4e7ea04eed81d78d3f6a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T07:53:18Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6e0ba4fb71cb4e7ea04eed81d78d3f6a2022-12-21T18:33:25ZengNature PortfolioNature Communications2041-17232020-05-0111111310.1038/s41467-020-16140-9mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1Yushen Du0Judd F. Hultquist1Quan Zhou2Anders Olson3Yenwen Tseng4Tian-hao Zhang5Mengying Hong6Kejun Tang7Liubo Chen8Xiangzhi Meng9Michael J. McGregor10Lei Dai11Danyang Gong12Laura Martin-Sancho13Sumit Chanda14Xinming Li15Steve Bensenger16Nevan J. Krogan17Ren Sun18Department of Molecular and Medical Pharmacology, University of CaliforniaDepartment of Cellular and Molecular Pharmacology, University of California, San FranciscoDepartment of Molecular and Medical Pharmacology, University of CaliforniaDepartment of Molecular and Medical Pharmacology, University of CaliforniaDepartment of Molecular and Medical Pharmacology, University of CaliforniaDepartment of Molecular and Medical Pharmacology, University of CaliforniaCancer Institute, ZJU-UCLA Joint Center for Medical Education and Research, School of Medicine, Zhejiang UniversityCancer Institute, ZJU-UCLA Joint Center for Medical Education and Research, School of Medicine, Zhejiang UniversityCancer Institute, ZJU-UCLA Joint Center for Medical Education and Research, School of Medicine, Zhejiang UniversityDepartment of Molecular and Medical Pharmacology, University of CaliforniaDepartment of Cellular and Molecular Pharmacology, University of California, San FranciscoDepartment of Molecular and Medical Pharmacology, University of CaliforniaDepartment of Molecular and Medical Pharmacology, University of CaliforniaSanford Burnham Prebys Medical Discovery InstituteSanford Burnham Prebys Medical Discovery InstituteDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, LDepartment of Molecular and Medical Pharmacology, University of CaliforniaDepartment of Cellular and Molecular Pharmacology, University of California, San FranciscoDepartment of Molecular and Medical Pharmacology, University of CaliforniaIdentification of low abundance proteins interacting with viral proteins can be challenging. Here, Du et al. develop an mRNA display approach with a library of even distribution, identify host proteins interacting with NS1 protein of influenza A virus, and show that one interactor provides a means to regulate cellular fatty acids synthesis.https://doi.org/10.1038/s41467-020-16140-9 |
| spellingShingle | Yushen Du Judd F. Hultquist Quan Zhou Anders Olson Yenwen Tseng Tian-hao Zhang Mengying Hong Kejun Tang Liubo Chen Xiangzhi Meng Michael J. McGregor Lei Dai Danyang Gong Laura Martin-Sancho Sumit Chanda Xinming Li Steve Bensenger Nevan J. Krogan Ren Sun mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1 Nature Communications |
| title | mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1 |
| title_full | mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1 |
| title_fullStr | mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1 |
| title_full_unstemmed | mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1 |
| title_short | mRNA display with library of even-distribution reveals cellular interactors of influenza virus NS1 |
| title_sort | mrna display with library of even distribution reveals cellular interactors of influenza virus ns1 |
| url | https://doi.org/10.1038/s41467-020-16140-9 |
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