Trichloroacetic acid fueled practical amine purifications
Amine purification have for long been dominated by tedious stepwise processes involving the generation of large amounts of undesired waste. Inspired by recent work on out of equilibrium molecular machinery, using trichloroacetic acid (TCA), we disclose a purification technique considerably decreasin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2022-02-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.18.26 |
| _version_ | 1819120592848158720 |
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| author | Aleena Thomas Baptiste Gasch Enzo Olivieri Adrien Quintard |
| author_facet | Aleena Thomas Baptiste Gasch Enzo Olivieri Adrien Quintard |
| author_sort | Aleena Thomas |
| collection | DOAJ |
| description | Amine purification have for long been dominated by tedious stepwise processes involving the generation of large amounts of undesired waste. Inspired by recent work on out of equilibrium molecular machinery, using trichloroacetic acid (TCA), we disclose a purification technique considerably decreasing the number of operations and the waste generation required for such purifications. At first, TCA triggers the precipitation of the amines through their protonated salt formation, enabling the separation with the impurities. From these amine salts, simple decarboxylation of TCA liberates volatile CO2 and chloroform affording directly the pure amines. Through this approach, a broad range of diversely substituted amines could be isolated with success. |
| first_indexed | 2024-12-22T06:23:07Z |
| format | Article |
| id | doaj.art-6e0cf9f0f4484a40aa88a074bf01b3c6 |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-22T06:23:07Z |
| publishDate | 2022-02-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-6e0cf9f0f4484a40aa88a074bf01b3c62022-12-21T18:35:55ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972022-02-0118122523110.3762/bjoc.18.261860-5397-18-26Trichloroacetic acid fueled practical amine purificationsAleena Thomas0Baptiste Gasch1Enzo Olivieri2Adrien Quintard3Aix-Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, FranceAix-Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, FranceAix-Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, FranceAix-Marseille Univ, CNRS, Centrale Marseille, iSm2, Marseille, FranceAmine purification have for long been dominated by tedious stepwise processes involving the generation of large amounts of undesired waste. Inspired by recent work on out of equilibrium molecular machinery, using trichloroacetic acid (TCA), we disclose a purification technique considerably decreasing the number of operations and the waste generation required for such purifications. At first, TCA triggers the precipitation of the amines through their protonated salt formation, enabling the separation with the impurities. From these amine salts, simple decarboxylation of TCA liberates volatile CO2 and chloroform affording directly the pure amines. Through this approach, a broad range of diversely substituted amines could be isolated with success.https://doi.org/10.3762/bjoc.18.26aminesdecarboxylationeco-compatibleout of equilibriumpurification |
| spellingShingle | Aleena Thomas Baptiste Gasch Enzo Olivieri Adrien Quintard Trichloroacetic acid fueled practical amine purifications Beilstein Journal of Organic Chemistry amines decarboxylation eco-compatible out of equilibrium purification |
| title | Trichloroacetic acid fueled practical amine purifications |
| title_full | Trichloroacetic acid fueled practical amine purifications |
| title_fullStr | Trichloroacetic acid fueled practical amine purifications |
| title_full_unstemmed | Trichloroacetic acid fueled practical amine purifications |
| title_short | Trichloroacetic acid fueled practical amine purifications |
| title_sort | trichloroacetic acid fueled practical amine purifications |
| topic | amines decarboxylation eco-compatible out of equilibrium purification |
| url | https://doi.org/10.3762/bjoc.18.26 |
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