Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents
Objective To investigate the association of the interaction between brain-derived neurotrophic factor (BDNF) gene and neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene with suicide attempt in adolescents. Methods One single nucleotide polymorphism (SNP) of BDNF gene (rs1491851) and 3 SNPs of...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2019-06-01
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| Series: | Di-san junyi daxue xuebao |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/201811215.htm |
| _version_ | 1818649438102487040 |
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| author | WU Tong RAN Liuyi JIN Jiajia WANG Suya LIU Wei |
| author_facet | WU Tong RAN Liuyi JIN Jiajia WANG Suya LIU Wei |
| author_sort | WU Tong |
| collection | DOAJ |
| description | Objective To investigate the association of the interaction between brain-derived neurotrophic factor (BDNF) gene and neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene with suicide attempt in adolescents. Methods One single nucleotide polymorphism (SNP) of BDNF gene (rs1491851) and 3 SNPs of NTRK2 (rs1147198, rs11140800, rs1565445) were tested by IMLDRtm multiplex SNP typing in 70 suicide attempters (15~24 years old) and 111 healthy young individuals (control). Analysis on gene-gene interaction was conducted by generalized multifactor dimensionality reduction (GMDR). Results No significant differences were found in genotype frequencies and allele frequencies between the attempters and controls at 4 SNPs (BDNF rs1491851, and NTRK2 rs1147198, rs1140800, rs1565445)(P>0.05). GMDR analysis indicated the interactions between BDNF gene and NTRK2 gene included a two-locus combination (rs1491851, rs1147198), a three-locus combination (rs1491851, rs1147198, rs11140800) and four-locus combination (rs1491851, rs1147198, rs11140800, rs1565445). The four-locus combination was identified as the best model (Bal. Acc. CV test: 0.632 5, CVC consistency: 10/10, permutation test: P=0.032~0.033). Conclusion There are interactions between BDNF gene and NTRK2 gene, which may be associated with suicide attempt in adolescents. |
| first_indexed | 2024-12-17T01:34:19Z |
| format | Article |
| id | doaj.art-6e0d8cbf49044512a9e0e30e35a5c831 |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-17T01:34:19Z |
| publishDate | 2019-06-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-6e0d8cbf49044512a9e0e30e35a5c8312022-12-21T22:08:29ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042019-06-0141111065106910.16016/j.1000-5404.201811215Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescentsWU Tong0RAN Liuyi1JIN Jiajia2WANG Suya3LIU Wei4Center for Mental Health, University-Town Hospital of Chongqing Medical University, Chongqing, 401331Center for Mental Health, University-Town Hospital of Chongqing Medical University, Chongqing, 401331Center for Mental Health, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, ChinaCenter for Mental Health, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, ChinaCenter for Mental Health, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, ChinaObjective To investigate the association of the interaction between brain-derived neurotrophic factor (BDNF) gene and neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene with suicide attempt in adolescents. Methods One single nucleotide polymorphism (SNP) of BDNF gene (rs1491851) and 3 SNPs of NTRK2 (rs1147198, rs11140800, rs1565445) were tested by IMLDRtm multiplex SNP typing in 70 suicide attempters (15~24 years old) and 111 healthy young individuals (control). Analysis on gene-gene interaction was conducted by generalized multifactor dimensionality reduction (GMDR). Results No significant differences were found in genotype frequencies and allele frequencies between the attempters and controls at 4 SNPs (BDNF rs1491851, and NTRK2 rs1147198, rs1140800, rs1565445)(P>0.05). GMDR analysis indicated the interactions between BDNF gene and NTRK2 gene included a two-locus combination (rs1491851, rs1147198), a three-locus combination (rs1491851, rs1147198, rs11140800) and four-locus combination (rs1491851, rs1147198, rs11140800, rs1565445). The four-locus combination was identified as the best model (Bal. Acc. CV test: 0.632 5, CVC consistency: 10/10, permutation test: P=0.032~0.033). Conclusion There are interactions between BDNF gene and NTRK2 gene, which may be associated with suicide attempt in adolescents.http://aammt.tmmu.edu.cn/Upload/rhtml/201811215.htmsuicide attemptbrain-derived neurotrophic factorneurotrophic tyrosine kinase receptor type 2gene-gene interactionmiddle and later adolescents |
| spellingShingle | WU Tong RAN Liuyi JIN Jiajia WANG Suya LIU Wei Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents Di-san junyi daxue xuebao suicide attempt brain-derived neurotrophic factor neurotrophic tyrosine kinase receptor type 2 gene-gene interaction middle and later adolescents |
| title | Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents |
| title_full | Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents |
| title_fullStr | Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents |
| title_full_unstemmed | Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents |
| title_short | Association of interaction between brain-derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents |
| title_sort | association of interaction between brain derived neurotrophic factor gene and neurotrophic tyrosine kinase receptor type 2 gene with suicide attempt in middle and later adolescents |
| topic | suicide attempt brain-derived neurotrophic factor neurotrophic tyrosine kinase receptor type 2 gene-gene interaction middle and later adolescents |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/201811215.htm |
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