Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5)
AimMetabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunom...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1011942/full |
| _version_ | 1811189207161372672 |
|---|---|
| author | Joy Manohar Sibi Viswanathan Mohan Mohan Deepa Subash Babu Vivekanandhan Aravindhan |
| author_facet | Joy Manohar Sibi Viswanathan Mohan Mohan Deepa Subash Babu Vivekanandhan Aravindhan |
| author_sort | Joy Manohar Sibi |
| collection | DOAJ |
| description | AimMetabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunomodulation. In the present study, we studied the effect of LF on endocrine dysfunction in MS and Non-MS patients in baseline and after 10 years of follow-up.MethodsWe quantified the serum levels of pancreatic hormones (insulin and glucagon), incretins (Ghrelin, GIP and GLP-1) and adipokines (leptin, adiponectin, adipsin, visfatin, PAI-1 and resistin) by multiplex bead array system.ResultsMS (both LF- and LF+) subjects had increased insulin levels compared to NMS (both LF- and LF+) subjects. MS-LF+ subjects had significantly increased levels of glucagon, ghrelin, GIP and GLP-1 and decreased levels of adipsin, compared to MS-LF- subjects. Interestingly this effect was short-lived and was not seen in the follow-up samples.ConclusionOverall, LF infection might confer limited short-term beneficial effects against MS, by means of modulating the incretin levels,either directly or indirectly. |
| first_indexed | 2024-04-11T14:31:59Z |
| format | Article |
| id | doaj.art-6e1050c694154378be7989a772183d73 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T14:31:59Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6e1050c694154378be7989a772183d732022-12-22T04:18:34ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10119421011942Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5)Joy Manohar Sibi0Viswanathan Mohan1Mohan Deepa2Subash Babu3Vivekanandhan Aravindhan4Department of Genetics, Dr. A. L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, IndiaMadras Diabetes Research Foundation and Dr. Mohan’s Diabetes Specialties Centre, ICMR Center for Advanced Research on Diabetes and IDF Centre of Excellence in Diabetes Care, Chennai, IndiaMadras Diabetes Research Foundation and Dr. Mohan’s Diabetes Specialties Centre, ICMR Center for Advanced Research on Diabetes and IDF Centre of Excellence in Diabetes Care, Chennai, IndiaNational Institute of Health-International Centre for Excellence in Research, National Institute for Research in Tuberculosis, Chennai, IndiaDepartment of Genetics, Dr. A. L. Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, IndiaAimMetabolic syndrome (MS) refers to a group of co-morbidities which include central obesity, hypertension, hyperglycemia and dyslipidemia. Previously, we reported that childhood lymphatic filariasis (LF) confers significant protection against type-1 and type-2 forms of diabetes, by means of immunomodulation. In the present study, we studied the effect of LF on endocrine dysfunction in MS and Non-MS patients in baseline and after 10 years of follow-up.MethodsWe quantified the serum levels of pancreatic hormones (insulin and glucagon), incretins (Ghrelin, GIP and GLP-1) and adipokines (leptin, adiponectin, adipsin, visfatin, PAI-1 and resistin) by multiplex bead array system.ResultsMS (both LF- and LF+) subjects had increased insulin levels compared to NMS (both LF- and LF+) subjects. MS-LF+ subjects had significantly increased levels of glucagon, ghrelin, GIP and GLP-1 and decreased levels of adipsin, compared to MS-LF- subjects. Interestingly this effect was short-lived and was not seen in the follow-up samples.ConclusionOverall, LF infection might confer limited short-term beneficial effects against MS, by means of modulating the incretin levels,either directly or indirectly.https://www.frontiersin.org/articles/10.3389/fendo.2022.1011942/fullmetabolic syndromefilariasisincretinsadipokinesinsulinglucagon |
| spellingShingle | Joy Manohar Sibi Viswanathan Mohan Mohan Deepa Subash Babu Vivekanandhan Aravindhan Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5) Frontiers in Endocrinology metabolic syndrome filariasis incretins adipokines insulin glucagon |
| title | Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5) |
| title_full | Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5) |
| title_fullStr | Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5) |
| title_full_unstemmed | Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5) |
| title_short | Modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome (DM-LF5) |
| title_sort | modulatory effect of filarial infection on the systemic hormone levels in subjects with metabolic syndrome dm lf5 |
| topic | metabolic syndrome filariasis incretins adipokines insulin glucagon |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1011942/full |
| work_keys_str_mv | AT joymanoharsibi modulatoryeffectoffilarialinfectiononthesystemichormonelevelsinsubjectswithmetabolicsyndromedmlf5 AT viswanathanmohan modulatoryeffectoffilarialinfectiononthesystemichormonelevelsinsubjectswithmetabolicsyndromedmlf5 AT mohandeepa modulatoryeffectoffilarialinfectiononthesystemichormonelevelsinsubjectswithmetabolicsyndromedmlf5 AT subashbabu modulatoryeffectoffilarialinfectiononthesystemichormonelevelsinsubjectswithmetabolicsyndromedmlf5 AT vivekanandhanaravindhan modulatoryeffectoffilarialinfectiononthesystemichormonelevelsinsubjectswithmetabolicsyndromedmlf5 |