In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells
The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modulate MT coherence and alignment to promote cancer ce...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17147-y |
| _version_ | 1819202162923667456 |
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| author | Gaurav Luthria Ran Li Stephanie Wang Mark Prytyskach Rainer H. Kohler Douglas A. Lauffenburger Timothy J. Mitchison Ralph Weissleder Miles A. Miller |
| author_facet | Gaurav Luthria Ran Li Stephanie Wang Mark Prytyskach Rainer H. Kohler Douglas A. Lauffenburger Timothy J. Mitchison Ralph Weissleder Miles A. Miller |
| author_sort | Gaurav Luthria |
| collection | DOAJ |
| description | The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modulate MT coherence and alignment to promote cancer cell migration. |
| first_indexed | 2024-12-23T03:59:39Z |
| format | Article |
| id | doaj.art-6e12c582f93443ddbaa1e7221c686a84 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T03:59:39Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6e12c582f93443ddbaa1e7221c686a842022-12-21T18:00:46ZengNature PortfolioNature Communications2041-17232020-07-0111111710.1038/s41467-020-17147-yIn vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cellsGaurav Luthria0Ran Li1Stephanie Wang2Mark Prytyskach3Rainer H. Kohler4Douglas A. Lauffenburger5Timothy J. Mitchison6Ralph Weissleder7Miles A. Miller8Center for Systems Biology, Massachusetts General Hospital Research InstituteCenter for Systems Biology, Massachusetts General Hospital Research InstituteDepartment of Biological Engineering, Massachusetts Institute of TechnologyCenter for Systems Biology, Massachusetts General Hospital Research InstituteCenter for Systems Biology, Massachusetts General Hospital Research InstituteDepartment of Biological Engineering, Massachusetts Institute of TechnologyDepartment of Systems Biology, Harvard Medical SchoolCenter for Systems Biology, Massachusetts General Hospital Research InstituteCenter for Systems Biology, Massachusetts General Hospital Research InstituteThe regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modulate MT coherence and alignment to promote cancer cell migration.https://doi.org/10.1038/s41467-020-17147-y |
| spellingShingle | Gaurav Luthria Ran Li Stephanie Wang Mark Prytyskach Rainer H. Kohler Douglas A. Lauffenburger Timothy J. Mitchison Ralph Weissleder Miles A. Miller In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells Nature Communications |
| title | In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells |
| title_full | In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells |
| title_fullStr | In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells |
| title_full_unstemmed | In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells |
| title_short | In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells |
| title_sort | in vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells |
| url | https://doi.org/10.1038/s41467-020-17147-y |
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