Dysregulated Interferon Response and Immune Hyperactivation in Severe COVID-19: Targeting STATs as a Novel Therapeutic Strategy

Dysregulated Interferon Response and Immune Hyperactivation in Severe COVID-19: Targeting STATs as a Novel Therapeutic Strategy

A disease outbreak in December 2019, caused by a novel coronavirus SARS-CoV-2, was named COVID-19. SARS-CoV-2 infects cells from the upper and lower respiratory tract system and is transmitted by inhalation or contact with infected droplets. Common clinical symptoms include fatigue, fever, and cough...

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Bibliographic Details
Main Authors: Mahdi Eskandarian Boroujeni, Agata Sekrecka, Aleksandra Antonczyk, Sanaz Hassani, Michal Sekrecki, Hanna Nowicka, Natalia Lopacinska, Arta Olya, Katarzyna Kluzek, Joanna Wesoly, Hans A. R. Bluyssen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
COVID – 19
interferon response
immune hyperactivation
multiple organ damage
STAT signaling
Statinhib
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.888897/full

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