Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review
Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fatal “post-antibiotic era” are evaluated. In commens...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/7/522 |
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| author | András Fodor Birhan Addisie Abate Péter Deák László Fodor Ervin Gyenge Michael G. Klein Zsuzsanna Koncz Josephat Muvevi László Ötvös Gyöngyi Székely Dávid Vozik László Makrai |
| author_facet | András Fodor Birhan Addisie Abate Péter Deák László Fodor Ervin Gyenge Michael G. Klein Zsuzsanna Koncz Josephat Muvevi László Ötvös Gyöngyi Székely Dávid Vozik László Makrai |
| author_sort | András Fodor |
| collection | DOAJ |
| description | Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fatal “post-antibiotic era” are evaluated. In commensal niches, the appearance of a new antibiotic resistance often reduces fitness, but compensatory mutations may counteract this tendency. The appearance of new antibiotic resistance is frequently accompanied by a collateral sensitivity to other resistances. Organisms with an expanding open pan-genome, such as <i>Acinetobacter baumannii, Pseudomonas aeruginosa</i>, and <i>Klebsiella pneumoniae</i>, can withstand an increased number of resistances by exploiting their evolutionary plasticity and disseminating clonally or poly-clonally. Multidrug-resistant pathogen clones can become predominant under antibiotic stress conditions but, under the influence of negative frequency-dependent selection, are prevented from rising to dominance in a population in a commensal niche. Antimicrobial peptides have a great potential to combat multidrug resistance, since antibiotic-resistant bacteria have shown a high frequency of collateral sensitivity to antimicrobial peptides. In addition, the mobility patterns of antibiotic resistance, and antimicrobial peptide resistance, genes are completely different. The integron trade in commensal niches is fortunately limited by the species-specificity of resistance genes. Hence, we theorize that the suggested post-antibiotic era has not yet come, and indeed might never come. |
| first_indexed | 2024-03-10T18:49:26Z |
| format | Article |
| id | doaj.art-6e1421dd69f94a678073310d05df321f |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T18:49:26Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-6e1421dd69f94a678073310d05df321f2023-11-20T05:16:21ZengMDPI AGPathogens2076-08172020-06-019752210.3390/pathogens9070522Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A ReviewAndrás Fodor0Birhan Addisie Abate1Péter Deák2László Fodor3Ervin Gyenge4Michael G. Klein5Zsuzsanna Koncz6Josephat Muvevi7László Ötvös8Gyöngyi Székely9Dávid Vozik10László Makrai11Department of Genetics, University of Szeged, H-6726 Szeged, HungaryEthiopian Biotechnology Institute, Agricultural Biotechnology Directorate, Addis Ababa 5954, EthiopiaDepartment of Genetics, University of Szeged, H-6726 Szeged, HungaryDepartment of Microbiology and Infectious Diseases, University of Veterinary Medicine, P.O. Box 22, H-1581 Budapest, HungaryHungarian Department of Biology and Ecology, Faculty of Biology and Geology, Babeș-Bolyai University, 5-7 Clinicilor St., 400006 Cluj-Napoca, RomaniaDepartment of Entomology, The Ohio State University, 1680 Madison Ave., Wooster, OH 44691, USAMax-Planck Institut für Pflanzenzüchtungsforschung, Carl-von-Linné-Weg 10, D-50829 Köln, GermanyNational Cereals and Produce Board, Mombasa 80100, KenyaOLPE, LLC, Audubon, PA 19403-1965, USAHungarian Department of Biology and Ecology, Faculty of Biology and Geology, Babeș-Bolyai University, 5-7 Clinicilor St., 400006 Cluj-Napoca, RomaniaResearch Institute on Bioengineering, Membrane Technology and Energetics, Faculty of Engineering, University of Veszprem, H-8200 Veszprém, HungaryDepartment of Microbiology and Infectious Diseases, University of Veterinary Medicine, P.O. Box 22, H-1581 Budapest, HungaryAntibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fatal “post-antibiotic era” are evaluated. In commensal niches, the appearance of a new antibiotic resistance often reduces fitness, but compensatory mutations may counteract this tendency. The appearance of new antibiotic resistance is frequently accompanied by a collateral sensitivity to other resistances. Organisms with an expanding open pan-genome, such as <i>Acinetobacter baumannii, Pseudomonas aeruginosa</i>, and <i>Klebsiella pneumoniae</i>, can withstand an increased number of resistances by exploiting their evolutionary plasticity and disseminating clonally or poly-clonally. Multidrug-resistant pathogen clones can become predominant under antibiotic stress conditions but, under the influence of negative frequency-dependent selection, are prevented from rising to dominance in a population in a commensal niche. Antimicrobial peptides have a great potential to combat multidrug resistance, since antibiotic-resistant bacteria have shown a high frequency of collateral sensitivity to antimicrobial peptides. In addition, the mobility patterns of antibiotic resistance, and antimicrobial peptide resistance, genes are completely different. The integron trade in commensal niches is fortunately limited by the species-specificity of resistance genes. Hence, we theorize that the suggested post-antibiotic era has not yet come, and indeed might never come.https://www.mdpi.com/2076-0817/9/7/522MDRintrinsic/acquired resistancecollateral sensitivitynegative frequency-dependent selectionexperimental evolutionpangenome |
| spellingShingle | András Fodor Birhan Addisie Abate Péter Deák László Fodor Ervin Gyenge Michael G. Klein Zsuzsanna Koncz Josephat Muvevi László Ötvös Gyöngyi Székely Dávid Vozik László Makrai Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review Pathogens MDR intrinsic/acquired resistance collateral sensitivity negative frequency-dependent selection experimental evolution pangenome |
| title | Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review |
| title_full | Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review |
| title_fullStr | Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review |
| title_full_unstemmed | Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review |
| title_short | Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review |
| title_sort | multidrug resistance mdr and collateral sensitivity in bacteria with special attention to genetic and evolutionary aspects and to the perspectives of antimicrobial peptides a review |
| topic | MDR intrinsic/acquired resistance collateral sensitivity negative frequency-dependent selection experimental evolution pangenome |
| url | https://www.mdpi.com/2076-0817/9/7/522 |
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