Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review

Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides—A Review

Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fatal “post-antibiotic era” are evaluated. In commens...

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Bibliographic Details
Main Authors: András Fodor, Birhan Addisie Abate, Péter Deák, László Fodor, Ervin Gyenge, Michael G. Klein, Zsuzsanna Koncz, Josephat Muvevi, László Ötvös, Gyöngyi Székely, Dávid Vozik, László Makrai
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Pathogens
Subjects:
MDR
intrinsic/acquired resistance
collateral sensitivity
negative frequency-dependent selection
experimental evolution
pangenome
Online Access:https://www.mdpi.com/2076-0817/9/7/522

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