Adverse Events of COVID-19 Vaccination among the Saudi Population: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis aimed to synthesize the evidence on the adverse events (AEs) of coronavirus disease 2019 (COVID-19) vaccinations in Saudi Arabia. A computerized search in MEDLINE via PubMed and OVID, Scopus, CENTRAL, and Web of Science was conducted using relevant keywords....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/12/2089 |
| _version_ | 1827636656534978560 |
|---|---|
| author | Abdulaziz Alhossan Amjad Khalid Alsaran Afnan Hussain Almahmudi Ziad Saad Aljohani Mohammed Rajeh Albishi Ahoud Khashman Almutairi |
| author_facet | Abdulaziz Alhossan Amjad Khalid Alsaran Afnan Hussain Almahmudi Ziad Saad Aljohani Mohammed Rajeh Albishi Ahoud Khashman Almutairi |
| author_sort | Abdulaziz Alhossan |
| collection | DOAJ |
| description | This systematic review and meta-analysis aimed to synthesize the evidence on the adverse events (AEs) of coronavirus disease 2019 (COVID-19) vaccinations in Saudi Arabia. A computerized search in MEDLINE via PubMed and OVID, Scopus, CENTRAL, and Web of Science was conducted using relevant keywords. The NIH tools were used for the quality assessment. A total of 14 studies (16 reports) were included. The pooled analysis showed that the incidence of AEs post-COVID-19 vaccination was 40.4% (95% CI:6.4% to 87%). Compared to the AstraZeneca vaccine, the Pfizer-BioNTech vaccine was associated with a lower risk ratio (RR) of wheezing (RR = 0.04), fever (RR = 0.32), chills (RR = 0.41), headache (RR = 0.47), dizziness (RR = 0.49), and joint pain (RR = 0.51). The Pfizer-BioNTech vaccine was associated with significantly higher RR of general allergic reactions (RR = 1.62), dyspnea (RR = 1.68), upper respiratory tract symptoms (RR = 1.71), and lymphadenopathy (RR = 8.32). The current evidence suggests that the incidence of AEs following COVID-19 vaccines is 40%; however, most of these AEs were mild and for a short time. The overall number of participants with AEs was higher in the Pfizer group compared to the AstraZeneca group; however, the AstraZeneca vaccine was associated with a higher RR of several AEs. |
| first_indexed | 2024-03-09T15:45:49Z |
| format | Article |
| id | doaj.art-6e16d837f2b545128357305b40e31b3d |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T15:45:49Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-6e16d837f2b545128357305b40e31b3d2023-11-24T18:32:33ZengMDPI AGVaccines2076-393X2022-12-011012208910.3390/vaccines10122089Adverse Events of COVID-19 Vaccination among the Saudi Population: A Systematic Review and Meta-AnalysisAbdulaziz Alhossan0Amjad Khalid Alsaran1Afnan Hussain Almahmudi2Ziad Saad Aljohani3Mohammed Rajeh Albishi4Ahoud Khashman Almutairi5Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh P.O. Box 11451, Saudi ArabiaCollege of Pharmacy, King Saud University, Riyadh P.O. Box 11451, Saudi ArabiaFaculty of Pharmacy, Umm Al Qura University, Makkah P.O. Box 21955, Saudi ArabiaFaculty of Pharmacy, University of Hail, Hail P.O. Box 2440, Saudi ArabiaFaculty of Pharmacy, Umm Al Qura University, Makkah P.O. Box 21955, Saudi ArabiaCollege of Pharmacy, Qassim University, Unaizah-Qassim P.O. Box 6699, Saudi ArabiaThis systematic review and meta-analysis aimed to synthesize the evidence on the adverse events (AEs) of coronavirus disease 2019 (COVID-19) vaccinations in Saudi Arabia. A computerized search in MEDLINE via PubMed and OVID, Scopus, CENTRAL, and Web of Science was conducted using relevant keywords. The NIH tools were used for the quality assessment. A total of 14 studies (16 reports) were included. The pooled analysis showed that the incidence of AEs post-COVID-19 vaccination was 40.4% (95% CI:6.4% to 87%). Compared to the AstraZeneca vaccine, the Pfizer-BioNTech vaccine was associated with a lower risk ratio (RR) of wheezing (RR = 0.04), fever (RR = 0.32), chills (RR = 0.41), headache (RR = 0.47), dizziness (RR = 0.49), and joint pain (RR = 0.51). The Pfizer-BioNTech vaccine was associated with significantly higher RR of general allergic reactions (RR = 1.62), dyspnea (RR = 1.68), upper respiratory tract symptoms (RR = 1.71), and lymphadenopathy (RR = 8.32). The current evidence suggests that the incidence of AEs following COVID-19 vaccines is 40%; however, most of these AEs were mild and for a short time. The overall number of participants with AEs was higher in the Pfizer group compared to the AstraZeneca group; however, the AstraZeneca vaccine was associated with a higher RR of several AEs.https://www.mdpi.com/2076-393X/10/12/2089COVID-19vaccineadverse eventsAstraZenecaPfizer-BioNTech |
| spellingShingle | Abdulaziz Alhossan Amjad Khalid Alsaran Afnan Hussain Almahmudi Ziad Saad Aljohani Mohammed Rajeh Albishi Ahoud Khashman Almutairi Adverse Events of COVID-19 Vaccination among the Saudi Population: A Systematic Review and Meta-Analysis Vaccines COVID-19 vaccine adverse events AstraZeneca Pfizer-BioNTech |
| title | Adverse Events of COVID-19 Vaccination among the Saudi Population: A Systematic Review and Meta-Analysis |
| title_full | Adverse Events of COVID-19 Vaccination among the Saudi Population: A Systematic Review and Meta-Analysis |
| title_fullStr | Adverse Events of COVID-19 Vaccination among the Saudi Population: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Adverse Events of COVID-19 Vaccination among the Saudi Population: A Systematic Review and Meta-Analysis |
| title_short | Adverse Events of COVID-19 Vaccination among the Saudi Population: A Systematic Review and Meta-Analysis |
| title_sort | adverse events of covid 19 vaccination among the saudi population a systematic review and meta analysis |
| topic | COVID-19 vaccine adverse events AstraZeneca Pfizer-BioNTech |
| url | https://www.mdpi.com/2076-393X/10/12/2089 |
| work_keys_str_mv | AT abdulazizalhossan adverseeventsofcovid19vaccinationamongthesaudipopulationasystematicreviewandmetaanalysis AT amjadkhalidalsaran adverseeventsofcovid19vaccinationamongthesaudipopulationasystematicreviewandmetaanalysis AT afnanhussainalmahmudi adverseeventsofcovid19vaccinationamongthesaudipopulationasystematicreviewandmetaanalysis AT ziadsaadaljohani adverseeventsofcovid19vaccinationamongthesaudipopulationasystematicreviewandmetaanalysis AT mohammedrajehalbishi adverseeventsofcovid19vaccinationamongthesaudipopulationasystematicreviewandmetaanalysis AT ahoudkhashmanalmutairi adverseeventsofcovid19vaccinationamongthesaudipopulationasystematicreviewandmetaanalysis |