Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma
Abstract Paediatric rhabdomyosarcoma (RMS) is a soft tissue malignancy of mesenchymal origin that is thought to arise as a consequence of derailed myogenic differentiation. Despite intensive treatment regimens, the prognosis for high-risk patients remains dismal. The cellular differentiation states...
Main Authors: | Jeff DeMartino, Michael T. Meister, Lindy L. Visser, Mariël Brok, Marian J. A. Groot Koerkamp, Amber K. L. Wezenaar, Laura S. Hiemcke-Jiwa, Terezinha de Souza, Johannes H. M. Merks, Anne C. Rios, Frank C. P. Holstege, Thanasis Margaritis, Jarno Drost |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-05-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-38886-8 |
Similar Items
-
Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes
by: Michael T Meister, et al.
Published: (2022-10-01) -
ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma
by: Catrin Heim, et al.
Published: (2023-08-01) -
Investigation of rhabdomyosarcoma cell-cell electrofusion
by: Yeo, Felix Chong Xian
Published: (2012) -
Maintenance Chemotherapy for Patients with Rhabdomyosarcoma
by: Gianni Bisogno, et al.
Published: (2023-08-01) -
Patient Reported Outcomes and Measures in Children with Rhabdomyosarcoma
by: Marloes van Gorp, et al.
Published: (2023-01-01)