Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans
HDL cholesterol, besides its function in lipid metabolism, plays a role in suppressing blood oxidation reactions and protecting vascular endothelial cells. The uric acid/HDL cholesterol ratio (UHR) has recently attracted attention as a new biomarker for evaluating interactions between inflammatory a...
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MDPI AG
2022-06-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/6/1422 |
| _version_ | 1827662061323157504 |
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| author | Byoungjin Park Dong-Hyuk Jung Yong-Jae Lee |
| author_facet | Byoungjin Park Dong-Hyuk Jung Yong-Jae Lee |
| author_sort | Byoungjin Park |
| collection | DOAJ |
| description | HDL cholesterol, besides its function in lipid metabolism, plays a role in suppressing blood oxidation reactions and protecting vascular endothelial cells. The uric acid/HDL cholesterol ratio (UHR) has recently attracted attention as a new biomarker for evaluating interactions between inflammatory and anti-inflammatory substances in the blood. This study aimed to investigate the longitudinal association between UHR and incident ischemic heart disease (IHD). Data from 16,455 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korean Health Insurance Review and Assessment (HIRA) were assessed. Over 50 months after baseline enrolment, 321 (2.0%) participants developed IHD. The HRs of incident IHD were 0.85 (95% CI, 0.55–1.29), 1.42 (95% CI, 0.94–2.13), and 1.57 (95% CI, 1.01–2.45) in the second, third, and fourth UHR quartiles, respectively, after adjusting for potential confounding variables. In the subgroup analysis by sex-specific quartile, women tended to have higher HRs in the highest UHR quartile. We found that high UHR values were positively associated with incident IHD in Koreans without diabetes. An increased UHR may be a useful measure by which to assess cardiovascular risk in the preclinical stage. |
| first_indexed | 2024-03-10T00:19:51Z |
| format | Article |
| id | doaj.art-6e178e74244142beb12ee6fc0b4f6fd2 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:19:51Z |
| publishDate | 2022-06-01 |
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| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-6e178e74244142beb12ee6fc0b4f6fd22023-11-23T15:44:33ZengMDPI AGBiomedicines2227-90592022-06-01106142210.3390/biomedicines10061422Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic KoreansByoungjin Park0Dong-Hyuk Jung1Yong-Jae Lee2Department of Family Medicine, Yongin Severance Hospital, Yongin-si 16995, KoreaDepartment of Family Medicine, Yongin Severance Hospital, Yongin-si 16995, KoreaDepartment of Family Medicine, Gangnam Severance Hospital, Seoul 06273, KoreaHDL cholesterol, besides its function in lipid metabolism, plays a role in suppressing blood oxidation reactions and protecting vascular endothelial cells. The uric acid/HDL cholesterol ratio (UHR) has recently attracted attention as a new biomarker for evaluating interactions between inflammatory and anti-inflammatory substances in the blood. This study aimed to investigate the longitudinal association between UHR and incident ischemic heart disease (IHD). Data from 16,455 participants without diabetes from the Health Risk Assessment Study (HERAS) and Korean Health Insurance Review and Assessment (HIRA) were assessed. Over 50 months after baseline enrolment, 321 (2.0%) participants developed IHD. The HRs of incident IHD were 0.85 (95% CI, 0.55–1.29), 1.42 (95% CI, 0.94–2.13), and 1.57 (95% CI, 1.01–2.45) in the second, third, and fourth UHR quartiles, respectively, after adjusting for potential confounding variables. In the subgroup analysis by sex-specific quartile, women tended to have higher HRs in the highest UHR quartile. We found that high UHR values were positively associated with incident IHD in Koreans without diabetes. An increased UHR may be a useful measure by which to assess cardiovascular risk in the preclinical stage.https://www.mdpi.com/2227-9059/10/6/1422uric acid to HDL cholesterol ratiocohort studyischemic heart diseaseKoreans |
| spellingShingle | Byoungjin Park Dong-Hyuk Jung Yong-Jae Lee Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans Biomedicines uric acid to HDL cholesterol ratio cohort study ischemic heart disease Koreans |
| title | Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans |
| title_full | Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans |
| title_fullStr | Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans |
| title_full_unstemmed | Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans |
| title_short | Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans |
| title_sort | predictive value of serum uric acid to hdl cholesterol ratio for incident ischemic heart disease in non diabetic koreans |
| topic | uric acid to HDL cholesterol ratio cohort study ischemic heart disease Koreans |
| url | https://www.mdpi.com/2227-9059/10/6/1422 |
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