3,5,3’-triiodo-L-thyronine- and 3,5-diiodo-L-thyronine- affected metabolic pathways in liver of LDL receptor deficient mice

3,5,3’-triiodo-L-thyronine- and 3,5-diiodo-L-thyronine- affected metabolic pathways in liver of LDL receptor deficient mice

3,5,3’-triiodo-L-thyronine (T3) and 3,5-diiodo-L-thyronine (T2), when administered to a model of familial hypercholesterolemia, i.e. low density lipoprotein receptor (LDLr)-knockout (Ldlr-/-) mice fed with a Western type diet (WTD), dramatically reduce circulating total and very low-density lipoprot...

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Bibliographic Details
Main Authors: Maria Moreno, Elena Silvestri, Maria Coppola, Ira J. Goldberg, Li-Shin Huang, Anna Maria Salzano, Fulvio D’Angelo, Joel R. Ehrenkranz, Fernando Goglia
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Physiology
Subjects:
•Iodothyronines
•liver
•cholesterol
•LDL receptor
•proteomics.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00545/full

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