An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats

An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats

The neurotransmitter glutamate plays an essential role in excitatory neurotransmission; however, excessive amounts of glutamate lead to excitotoxicity, which is the most common pathogenic feature of numerous brain disorders. This study aimed to investigate the role of butyl 2-[2-(2-fluorophenyl)acet...

Full description

Bibliographic Details
Main Authors:	Cheng-Wei Lu, Chen-Jung Lin, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Tzu-Yu Lin, Su-Jane Wang
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	International Journal of Molecular Sciences
Subjects:	anthranilate derivative glutamate release glutamate excitotoxicity neuroprotection synaptosomes kainic acid
Online Access:	https://www.mdpi.com/1422-0067/23/5/2641

Similar Items

Inhibition of Synaptic Glutamate Exocytosis and Prevention of Glutamate Neurotoxicity by Eupatilin from <i>Artemisia argyi</i> in the Rat Cortex
by: Cheng-Wei Lu, et al.
Published: (2022-11-01)

Silymarin Inhibits Glutamate Release and Prevents against Kainic Acid-Induced Excitotoxic Injury in Rats
by: Cheng-Wei Lu, et al.
Published: (2020-11-01)

Glutamate excitotoxicity in multiple sclerosis
by: A. A. Ryazantseva, et al.
Published: (2017-02-01)

Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke
by: Zihuan Shen, et al.
Published: (2022-07-01)

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release
by: Shaimaa Mahmoud, et al.
Published: (2019-02-01)

Glutamate transporters and excitotoxicity in nervous system
by: Shahraki A (PhD), et al.
Published: (2011-09-01)

NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes
by: Shaimaa Mahmoud, et al.
Published: (2019-04-01)

Inhibition of Glutamate Release from Rat Cortical Nerve Terminals by Dehydrocorydaline, an Alkaloid from <i>Corydalis yanhusuo</i>
by: Tzu-Yu Lin, et al.
Published: (2022-01-01)

Piperine Provides Neuroprotection against Kainic Acid-Induced Neurotoxicity via Maintaining NGF Signalling Pathway
by: Ting-Yang Hsieh, et al.
Published: (2022-04-01)

The Key Role of Astrocytes in Amyotrophic Lateral Sclerosis and Their Commitment to Glutamate Excitotoxicity
by: Francesca Provenzano, et al.
Published: (2023-10-01)

Amiodarone reduces depolarization-evoked glutamate release from hippocampual synaptosomes
by: Chia Yu Chang, et al.
Published: (2017-03-01)

Glutamate Scavenging as a Neuroreparative Strategy in Ischemic Stroke
by: Oykum Kaplan-Arabaci, et al.
Published: (2022-03-01)

Enmein Decreases Synaptic Glutamate Release and Protects against Kainic Acid-Induced Brain Injury in Rats
by: Cheng-Wei Lu, et al.
Published: (2021-11-01)

Plantainoside D Reduces Depolarization-Evoked Glutamate Release from Rat Cerebral Cortical Synaptosomes
by: Kuan-Ming Chiu, et al.
Published: (2023-01-01)

Increased vesicular glutamate transporter expression causes excitotoxic neurodegeneration
by: Richard W. Daniels, et al.
Published: (2011-02-01)

Surface Properties of Synaptosomes in the Presence of L-Glutamic and Kainic Acids: In Vitro Alteration of the ATPase and Acetylcholinesterase Activities
by: Virjinia Doltchinkova, et al.
Published: (2021-12-01)

Protective effect of naringenin on glutamate-induced neurotoxicity in cultured hippocampal cells
by: Xu Xiao-Hui, et al.
Published: (2015-01-01)

Blocking ERK-DAPK1 Axis Attenuates Glutamate Excitotoxicity in Epilepsy
by: Chen-Ling Gan, et al.
Published: (2022-06-01)

Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake
by: Antonietta Gentile, et al.
Published: (2018-01-01)

Excitotoxic glutamate causes neuronal insulin resistance by inhibiting insulin receptor/Akt/mTOR pathway
by: Igor Pomytkin, et al.
Published: (2019-12-01)

Exploration of the glutamate-mediated retinal excitotoxic damage: a rat model of retinal neurodegeneration
by: Ling Gao, et al.
Published: (2018-11-01)

Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening
by: Anissa Rym Saidia, et al.
Published: (2024-01-01)

Effect of glutamate on autophagy induced by energy stress in SH-SY5Y neurons
by: Vukotić Tatjana, et al.
Published: (2017-01-01)

Enhanced recruitment of glutamate receptors underlies excitotoxicity of mitral cells in acute hyperammonemia
by: Mingxian Li, et al.
Published: (2022-10-01)

Cleavage of the vesicular glutamate transporters under excitotoxic conditions
by: Andrea C. Lobo, et al.
Published: (2011-12-01)

Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons
by: Henry C. Tseng, et al.
Published: (2005-06-01)

The Effects of NAD+ on Apoptotic Neuronal Death and Mitochondrial Biogenesis and Function after Glutamate Excitotoxicity
by: Xiaowan Wang, et al.
Published: (2014-11-01)

Nuclear factor erythroid 2-related factor 2 agonist protects retinal ganglion cells in glutamate excitotoxicity retinas
by: Yaqiong An, et al.
Published: (2022-09-01)

Neuroprotective Effects of Neuropeptide Y on Human Neuroblastoma SH-SY5Y Cells in Glutamate Excitotoxicity and ER Stress Conditions
by: Viswanthram Palanivel, et al.
Published: (2022-11-01)

Natural Product Isoliquiritigenin Activates GABA<sub>B</sub> Receptors to Decrease Voltage-Gate Ca<sup>2+</sup> Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals
by: Tzu-Yu Lin, et al.
Published: (2021-10-01)

A circuit-dependent ROS feedback loop mediates glutamate excitotoxicity to sculpt the Drosophila motor system
by: Jhan-Jie Peng, et al.
Published: (2019-07-01)

Kainic Acid and MPP+ Induce Upregulation of GLT-1 in Neuroblastoma and Glia Cells
by: Rabia UYARICI, et al.
Published: (2021-04-01)

Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease
by: Tiziana Bonifacino, et al.
Published: (2016-11-01)

Neuroprotection from Excitotoxic Injury by Local Administration of Lipid Emulsion into the Brain of Rats
by: Motomasa Tanioka, et al.
Published: (2020-04-01)

Glutamate excitotoxicity induced by orally administered propionic acid, a short chain fatty acid can be ameliorated by bee pollen
by: Afaf El-Ansary, et al.
Published: (2017-05-01)

Increased expression and function of glutamate transporters in multiple sclerosis
by: Ainara Vallejo-Illarramendi, et al.
Published: (2006-01-01)

Phillygenin Suppresses Glutamate Exocytosis in Rat Cerebrocortical Nerve Terminals (Synaptosomes) through the Inhibition of Ca<sub>v</sub>2.2 Calcium Channels
by: Ming-Yi Lee, et al.
Published: (2024-02-01)

Glutamate Carrier Involvement in Mitochondrial Dysfunctioning in the Brain White Matter
by: Anne E. J. Hillen, et al.
Published: (2020-07-01)

Low Dose Administration of Glutamate Triggers a Non-Apoptotic, Autophagic Response in PC12 Cells
by: Eleni Stamoula, et al.
Published: (2015-11-01)

Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures
by: Eduardo Octaviano Primini, et al.
Published: (2019-05-01)