Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population
Killer cell immunoglobulin-like receptors (KIR) exhibit extensive diversity, giving rise to different KIR profiles in populations worldwide. This study aimed to investigate the distribution of KIR genes and HLA ligands in a population from Campinas, southeastern Brazil (n = 292), and to compare th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-07-01
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| Series: | Innate Immunity |
| Online Access: | https://doi.org/10.1177/17534259231178592 |
| _version_ | 1797777712402661376 |
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| author | Daniela Maira Cardozo Amanda Vansan Marangon Fernando Guimarães Silvia Marques Sofia Lieber Márcia Delamain Francisco Aranha Jeane Eliete Laguila Visentainer Cármino Antonio de Souza |
| author_facet | Daniela Maira Cardozo Amanda Vansan Marangon Fernando Guimarães Silvia Marques Sofia Lieber Márcia Delamain Francisco Aranha Jeane Eliete Laguila Visentainer Cármino Antonio de Souza |
| author_sort | Daniela Maira Cardozo |
| collection | DOAJ |
| description | Killer cell immunoglobulin-like receptors (KIR) exhibit extensive diversity, giving rise to different KIR profiles in populations worldwide. This study aimed to investigate the distribution of KIR genes and HLA ligands in a population from Campinas, southeastern Brazil (n = 292), and to compare their results with other populations. A comprehensive analysis of population-specific genes, genotype, and haplotype frequencies of KIR may facilitate a better understanding of their evolution and role in immunity. The genotyping of 16 KIR genes and HLA class I alleles was performed by the reverse sequence-specific oligonucleotide methodology using the Luminex platform (One Lambda, Inc., Canoga Park, CA). The framework genes were present in all individuals, with the most common non-framework KIR genes detected being KIR2DP1(96.6%), KIR2DL1(95.5%), KIR3DL1(94.5%), KIR2DS4(93.8%) and KIR2DL3(87.3%). KIR2DS1, KIR2DS3, KIR2DS5, and KIR3DS1 presented frequencies below 40%. KIR2DL2, KIR2DL5, and KIR2DS2 showed intermediate frequencies (between53% and 58%). The activating gene KIR2DS5 was the least common in this population (30.8%). Forty-five KIR profiles were found with the commonest being the homozygous A haplotype (27.4%). The distribution of KIR genes in the Brazilian population is similar to Caucasian European and Euro-descendant populations. |
| first_indexed | 2024-03-12T23:08:37Z |
| format | Article |
| id | doaj.art-6e1a9f8526e94b4fbe2da988ec4ea791 |
| institution | Directory Open Access Journal |
| issn | 1753-4259 1753-4267 |
| language | English |
| last_indexed | 2024-03-12T23:08:37Z |
| publishDate | 2023-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Innate Immunity |
| spelling | doaj.art-6e1a9f8526e94b4fbe2da988ec4ea7912023-07-18T09:33:52ZengSAGE PublishingInnate Immunity1753-42591753-42672023-07-012910.1177/17534259231178592Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian populationDaniela Maira Cardozo0Amanda Vansan Marangon1Fernando Guimarães2Silvia Marques3Sofia Lieber4Márcia Delamain5Francisco Aranha6Jeane Eliete Laguila Visentainer7Cármino Antonio de Souza8 Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil Universidade Estadual de Campinas, Centro de Atenção Integral a Saúde da Mulher, Campinas, Brazil Universidade Estadual de Campinas, Laboratório de Imunogenética, Hemocentro, Campinas, Brazil Universidade Estadual de Campinas, Laboratório de Imunogenética, Hemocentro, Campinas, Brazil Universidade Estadual de Campinas, Hemocentro, Campinas, Brazil Universidade Estadual de Campinas, Hemocentro, Campinas, Brazil Universidade Estadual de Maringá, Laboratório de Imunogenética, Campinas, Brazil Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, BrazilKiller cell immunoglobulin-like receptors (KIR) exhibit extensive diversity, giving rise to different KIR profiles in populations worldwide. This study aimed to investigate the distribution of KIR genes and HLA ligands in a population from Campinas, southeastern Brazil (n = 292), and to compare their results with other populations. A comprehensive analysis of population-specific genes, genotype, and haplotype frequencies of KIR may facilitate a better understanding of their evolution and role in immunity. The genotyping of 16 KIR genes and HLA class I alleles was performed by the reverse sequence-specific oligonucleotide methodology using the Luminex platform (One Lambda, Inc., Canoga Park, CA). The framework genes were present in all individuals, with the most common non-framework KIR genes detected being KIR2DP1(96.6%), KIR2DL1(95.5%), KIR3DL1(94.5%), KIR2DS4(93.8%) and KIR2DL3(87.3%). KIR2DS1, KIR2DS3, KIR2DS5, and KIR3DS1 presented frequencies below 40%. KIR2DL2, KIR2DL5, and KIR2DS2 showed intermediate frequencies (between53% and 58%). The activating gene KIR2DS5 was the least common in this population (30.8%). Forty-five KIR profiles were found with the commonest being the homozygous A haplotype (27.4%). The distribution of KIR genes in the Brazilian population is similar to Caucasian European and Euro-descendant populations.https://doi.org/10.1177/17534259231178592 |
| spellingShingle | Daniela Maira Cardozo Amanda Vansan Marangon Fernando Guimarães Silvia Marques Sofia Lieber Márcia Delamain Francisco Aranha Jeane Eliete Laguila Visentainer Cármino Antonio de Souza Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population Innate Immunity |
| title | Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population |
| title_full | Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population |
| title_fullStr | Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population |
| title_full_unstemmed | Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population |
| title_short | Killer cell immunoglobulin-like receptor (KIR) genes and their HLA ligands in a Brazilian population |
| title_sort | killer cell immunoglobulin like receptor kir genes and their hla ligands in a brazilian population |
| url | https://doi.org/10.1177/17534259231178592 |
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