The Effect of <i>Helicobacter pylori</i> Eradication on Lipid Levels: A Meta-Analysis
<b>Introduction: </b><i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid level...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/5/904 |
| _version_ | 1797395301817909248 |
|---|---|
| author | Jun Watanabe Masato Hamasaki Kazuhiko Kotani |
| author_facet | Jun Watanabe Masato Hamasaki Kazuhiko Kotani |
| author_sort | Jun Watanabe |
| collection | DOAJ |
| description | <b>Introduction: </b><i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid levels following <i>H. pylori</i> eradication. <b>Methods:</b> A PubMed database was searched until December 2020 to identify randomized control trials (RCTs) and non-RCTs investigating the effect of <i>H. pylori</i> eradication on the lipid levels in inverse variance-weighted, random-effects meta-analyses. <b>Results:</b> A total of 24 studies (four RCTs and 20 non-RCTs) with 5270 participants were identified. The post-eradication levels were increased for high-density lipoprotein cholesterol (HDL-C; mean difference (MD) 2.28 mg/dL, 95% confidence interval (CI) 1.90 to 2.66) and triglyceride (TG; MD 3.22 mg/dL, 95% CI 1.13 to 5.31) compared with the pre-eradication levels. <i>H. pylori</i> eradication resulted in little to no difference in the low-density lipoprotein-cholesterol levels (MD −2.33 mg/dL, 95% CI −4.92 to 0.26). In the analyses of RCTs only, the findings for elevated HDL-C levels, but not TG, were robust. <b>Conclusions: </b><i>H. pylori</i> eradication increases the HDL-C levels. Further studies are needed to elucidate the effects of lipid changes following <i>H. pylori</i> eradication on cardiovascular diseases. |
| first_indexed | 2024-03-09T00:33:28Z |
| format | Article |
| id | doaj.art-6e1bca08938a43ceb7b9461c22f62899 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T00:33:28Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6e1bca08938a43ceb7b9461c22f628992023-12-11T18:22:07ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110590410.3390/jcm10050904The Effect of <i>Helicobacter pylori</i> Eradication on Lipid Levels: A Meta-AnalysisJun Watanabe0Masato Hamasaki1Kazuhiko Kotani2Division of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, JapanDivision of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, JapanDivision of Community and Family Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-City, Tochigi 329-0498, Japan<b>Introduction: </b><i>Helicobacter pylori</i> (<i>H. pylori</i>) infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid levels following <i>H. pylori</i> eradication. <b>Methods:</b> A PubMed database was searched until December 2020 to identify randomized control trials (RCTs) and non-RCTs investigating the effect of <i>H. pylori</i> eradication on the lipid levels in inverse variance-weighted, random-effects meta-analyses. <b>Results:</b> A total of 24 studies (four RCTs and 20 non-RCTs) with 5270 participants were identified. The post-eradication levels were increased for high-density lipoprotein cholesterol (HDL-C; mean difference (MD) 2.28 mg/dL, 95% confidence interval (CI) 1.90 to 2.66) and triglyceride (TG; MD 3.22 mg/dL, 95% CI 1.13 to 5.31) compared with the pre-eradication levels. <i>H. pylori</i> eradication resulted in little to no difference in the low-density lipoprotein-cholesterol levels (MD −2.33 mg/dL, 95% CI −4.92 to 0.26). In the analyses of RCTs only, the findings for elevated HDL-C levels, but not TG, were robust. <b>Conclusions: </b><i>H. pylori</i> eradication increases the HDL-C levels. Further studies are needed to elucidate the effects of lipid changes following <i>H. pylori</i> eradication on cardiovascular diseases.https://www.mdpi.com/2077-0383/10/5/904cardiovascular diseaseinflammation<i>Helicobacter</i> infectionhigh-density lipoproteinlipid metabolismtriglyceride |
| spellingShingle | Jun Watanabe Masato Hamasaki Kazuhiko Kotani The Effect of <i>Helicobacter pylori</i> Eradication on Lipid Levels: A Meta-Analysis Journal of Clinical Medicine cardiovascular disease inflammation <i>Helicobacter</i> infection high-density lipoprotein lipid metabolism triglyceride |
| title | The Effect of <i>Helicobacter pylori</i> Eradication on Lipid Levels: A Meta-Analysis |
| title_full | The Effect of <i>Helicobacter pylori</i> Eradication on Lipid Levels: A Meta-Analysis |
| title_fullStr | The Effect of <i>Helicobacter pylori</i> Eradication on Lipid Levels: A Meta-Analysis |
| title_full_unstemmed | The Effect of <i>Helicobacter pylori</i> Eradication on Lipid Levels: A Meta-Analysis |
| title_short | The Effect of <i>Helicobacter pylori</i> Eradication on Lipid Levels: A Meta-Analysis |
| title_sort | effect of i helicobacter pylori i eradication on lipid levels a meta analysis |
| topic | cardiovascular disease inflammation <i>Helicobacter</i> infection high-density lipoprotein lipid metabolism triglyceride |
| url | https://www.mdpi.com/2077-0383/10/5/904 |
| work_keys_str_mv | AT junwatanabe theeffectofihelicobacterpyloriieradicationonlipidlevelsametaanalysis AT masatohamasaki theeffectofihelicobacterpyloriieradicationonlipidlevelsametaanalysis AT kazuhikokotani theeffectofihelicobacterpyloriieradicationonlipidlevelsametaanalysis AT junwatanabe effectofihelicobacterpyloriieradicationonlipidlevelsametaanalysis AT masatohamasaki effectofihelicobacterpyloriieradicationonlipidlevelsametaanalysis AT kazuhikokotani effectofihelicobacterpyloriieradicationonlipidlevelsametaanalysis |