Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium
BackgroundWe previously demonstrated that flurbiprofen increased arterial oxygen partial pressure and reduced intrapulmonary shunts. The present study aims to investigate whether flurbiprofen improves intraoperative regional cerebral oxygen saturation (rScO2) and reduces the incidence of postoperati...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.889637/full |
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| author | Liang Shen Liang Shen Jia-qi Chen Xin-lu Yang Ji-cheng Hu Wei Gao Xiao-qing Chai Di Wang Di Wang |
| author_facet | Liang Shen Liang Shen Jia-qi Chen Xin-lu Yang Ji-cheng Hu Wei Gao Xiao-qing Chai Di Wang Di Wang |
| author_sort | Liang Shen |
| collection | DOAJ |
| description | BackgroundWe previously demonstrated that flurbiprofen increased arterial oxygen partial pressure and reduced intrapulmonary shunts. The present study aims to investigate whether flurbiprofen improves intraoperative regional cerebral oxygen saturation (rScO2) and reduces the incidence of postoperative delirium (POD) in elderly patients undergoing one-lung ventilation (OLV).MethodsOne hundred and twenty patients undergoing thoracoscopic lobectomy were randomly assigned to the flurbiprofen-treated group (n = 60) and the control-treated group (n = 60). Flurbiprofen was intravenously administered 20 minutes before skin incision. The rScO2 and partial pressure of arterial oxygen (PaO2) were recorded during the surgery, and POD was measured by the Confusion Assessment Method (CAM) within 5 days after surgery. The study was registered in the Chinese Clinical Trial Registry with the number ChiCTR1800020032.ResultsCompared with the control group, treatment with flurbiprofen significantly improved the mean value of intraoperative rScO2 as well as the PaO2 value (P < 0.05, both) and significantly reduced the baseline values of the rScO2 area under threshold (AUT) (P < 0.01) at 15, 30, and 60 min after OLV in the flurbiprofen-treated group. After surgery, the POD incidence in the flurbiprofen-treated group was significantly decreased compared with that in the control group (P < 0.05).ConclusionTreatment with flurbiprofen may improve rScO2 and reduce the incidence of POD in elderly patients undergoing thoracoscopic one-lung ventilation surgery for lung cancer.Clinical trial registrationhttp://www.chictr.org/cn/, identifier ChiCTR1800020032. |
| first_indexed | 2024-03-13T07:07:37Z |
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| language | English |
| last_indexed | 2024-03-13T07:07:37Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-6e1e8071ea6c409380701c32fa1efac62023-06-06T07:32:36ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-08-011310.3389/fpsyt.2022.889637889637Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative deliriumLiang Shen0Liang Shen1Jia-qi Chen2Xin-lu Yang3Ji-cheng Hu4Wei Gao5Xiao-qing Chai6Di Wang7Di Wang8Department of Anesthesiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, ChinaPain Clinic, Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, ChinaPain Clinic, Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, ChinaPain Clinic, Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, ChinaPain Clinic, Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, ChinaPain Clinic, Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, ChinaPain Clinic, Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, ChinaDepartment of Anesthesiology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, ChinaPain Clinic, Department of Anesthesiology, First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, ChinaBackgroundWe previously demonstrated that flurbiprofen increased arterial oxygen partial pressure and reduced intrapulmonary shunts. The present study aims to investigate whether flurbiprofen improves intraoperative regional cerebral oxygen saturation (rScO2) and reduces the incidence of postoperative delirium (POD) in elderly patients undergoing one-lung ventilation (OLV).MethodsOne hundred and twenty patients undergoing thoracoscopic lobectomy were randomly assigned to the flurbiprofen-treated group (n = 60) and the control-treated group (n = 60). Flurbiprofen was intravenously administered 20 minutes before skin incision. The rScO2 and partial pressure of arterial oxygen (PaO2) were recorded during the surgery, and POD was measured by the Confusion Assessment Method (CAM) within 5 days after surgery. The study was registered in the Chinese Clinical Trial Registry with the number ChiCTR1800020032.ResultsCompared with the control group, treatment with flurbiprofen significantly improved the mean value of intraoperative rScO2 as well as the PaO2 value (P < 0.05, both) and significantly reduced the baseline values of the rScO2 area under threshold (AUT) (P < 0.01) at 15, 30, and 60 min after OLV in the flurbiprofen-treated group. After surgery, the POD incidence in the flurbiprofen-treated group was significantly decreased compared with that in the control group (P < 0.05).ConclusionTreatment with flurbiprofen may improve rScO2 and reduce the incidence of POD in elderly patients undergoing thoracoscopic one-lung ventilation surgery for lung cancer.Clinical trial registrationhttp://www.chictr.org/cn/, identifier ChiCTR1800020032.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.889637/fullflurbiprofenone-lung ventilationregional cerebral oxygen saturationpostoperative deliriumthoracic surgery |
| spellingShingle | Liang Shen Liang Shen Jia-qi Chen Xin-lu Yang Ji-cheng Hu Wei Gao Xiao-qing Chai Di Wang Di Wang Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium Frontiers in Psychiatry flurbiprofen one-lung ventilation regional cerebral oxygen saturation postoperative delirium thoracic surgery |
| title | Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium |
| title_full | Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium |
| title_fullStr | Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium |
| title_full_unstemmed | Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium |
| title_short | Flurbiprofen used in one-lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium |
| title_sort | flurbiprofen used in one lung ventilation improves intraoperative regional cerebral oxygen saturation and reduces the incidence of postoperative delirium |
| topic | flurbiprofen one-lung ventilation regional cerebral oxygen saturation postoperative delirium thoracic surgery |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.889637/full |
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