SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity
The SARS-CoV-2 viral load may have importance in assessing COVID-19's pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity. The severity of the disease has been attributed to the dysregulated immune mechanisms, but studies have suggested a correlation between dis...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Medical Evidence |
| Subjects: | |
| Online Access: | http://www.journaljme.org/article.asp?issn=2667-0720;year=2021;volume=2;issue=3;spage=222;epage=227;aulast=Kapoor |
| _version_ | 1811290085098782720 |
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| author | Mayank Kapoor Prasan Kumar Panda |
| author_facet | Mayank Kapoor Prasan Kumar Panda |
| author_sort | Mayank Kapoor |
| collection | DOAJ |
| description | The SARS-CoV-2 viral load may have importance in assessing COVID-19's pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity. The severity of the disease has been attributed to the dysregulated immune mechanisms, but studies have suggested a correlation between disease severity and viral loads although evidence is not strong enough in justifying the same. Viraemia is shown to be keenly related to the disease progression. Viraemia has an association with increased Interleukin-6 levels and poorer prognosis. In terms of symptomatology, any definite correlations are not yet deduced, with no difference in viral loads among symptomatic and asymptomatic individuals. Reduction of viral load may be used as a marker of treatment success. Cycle threshold (Ct) values correlate with the SARS-CoV-2 viral loads. Ct values have shown a correlation with viral cultures and sub-genomic RNA values, both of which are considered the gold standard for determining infectivity but are expensive. Thereby, Ct value titres form an economical basis for deciding the de-isolation of the patients, which has implications in better resource management. Various limitations of viral load testing, especially of Ct values including human and laboratory factors are also discussed. |
| first_indexed | 2024-04-13T04:06:37Z |
| format | Article |
| id | doaj.art-6e1f1809290e4206b6a6246110fd74a6 |
| institution | Directory Open Access Journal |
| issn | 2667-0720 2667-0739 |
| language | English |
| last_indexed | 2024-04-13T04:06:37Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Evidence |
| spelling | doaj.art-6e1f1809290e4206b6a6246110fd74a62022-12-22T03:03:14ZengWolters Kluwer Medknow PublicationsJournal of Medical Evidence2667-07202667-07392021-01-012322222710.4103/JME.JME_134_20SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivityMayank KapoorPrasan Kumar PandaThe SARS-CoV-2 viral load may have importance in assessing COVID-19's pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity. The severity of the disease has been attributed to the dysregulated immune mechanisms, but studies have suggested a correlation between disease severity and viral loads although evidence is not strong enough in justifying the same. Viraemia is shown to be keenly related to the disease progression. Viraemia has an association with increased Interleukin-6 levels and poorer prognosis. In terms of symptomatology, any definite correlations are not yet deduced, with no difference in viral loads among symptomatic and asymptomatic individuals. Reduction of viral load may be used as a marker of treatment success. Cycle threshold (Ct) values correlate with the SARS-CoV-2 viral loads. Ct values have shown a correlation with viral cultures and sub-genomic RNA values, both of which are considered the gold standard for determining infectivity but are expensive. Thereby, Ct value titres form an economical basis for deciding the de-isolation of the patients, which has implications in better resource management. Various limitations of viral load testing, especially of Ct values including human and laboratory factors are also discussed.http://www.journaljme.org/article.asp?issn=2667-0720;year=2021;volume=2;issue=3;spage=222;epage=227;aulast=Kapoorcoronaviruscycle thresholdcytokine stormnasopharyngeal swabviremia |
| spellingShingle | Mayank Kapoor Prasan Kumar Panda SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity Journal of Medical Evidence coronavirus cycle threshold cytokine storm nasopharyngeal swab viremia |
| title | SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity |
| title_full | SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity |
| title_fullStr | SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity |
| title_full_unstemmed | SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity |
| title_short | SARS-CoV-2 viral load: Implication in COVID-19 pathogenesis, clinical presentation, diagnosis, treatment, prognosis and infectivity |
| title_sort | sars cov 2 viral load implication in covid 19 pathogenesis clinical presentation diagnosis treatment prognosis and infectivity |
| topic | coronavirus cycle threshold cytokine storm nasopharyngeal swab viremia |
| url | http://www.journaljme.org/article.asp?issn=2667-0720;year=2021;volume=2;issue=3;spage=222;epage=227;aulast=Kapoor |
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